| In vivo evidence for long-term CNS toxicity, associated with chronic binge use of methamphetamine. | |
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MedLine Citation:
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PMID: 20566251 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to examine disturbances in regional cerebral blood flow (rCBF) associated with methamphetamine abuse. METHODS: Using Single Photon Emission Computed Tomography (SPECT), rCBF was measured in 20 men who had previously injected methamphetamine intravenously for over 30 months and who were now abstinent for a minimum of 9 months and for an average of 2 years. Values were compared with those in 12 healthy men who had never injected methamphetamine. RESULTS: While rCBF was significantly and disproportionately reduced in subcortical and dorsal cortical brain regions, including the striatum, thalamus, cingulum, mesiodorsal prefrontal cortex, and pons (all t's>8.3 after global normalization, corrected p's<0.001), whole brain CBF was also significantly reduced in the former methamphetamine users. Binge use of methamphetamine is associated with long-term changes in both global and regional blood flows, likely representing severe and enduring neural toxicity of monoaminergic neurotransmitter systems in the brain, producing a pattern of hypoperfusion that resembles patterns reported previously for persons with atypical Parkinson's disease. CONCLUSIONS: These findings suggest that methamphetamine abusers may be possibly at increased risk for neurodegenerative diseases later in life. |
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Authors:
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Yong An Chung; Bradley S Peterson; Sujung J Yoon; Sung-Nam Cho; Sukhi Chai; Jaeseung Jeong; Dai Jin Kim |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-06-20 |
Journal Detail:
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Title: Drug and alcohol dependence Volume: 111 ISSN: 1879-0046 ISO Abbreviation: Drug Alcohol Depend Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-12-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7513587 Medline TA: Drug Alcohol Depend Country: Ireland |
Other Details:
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Languages: eng Pagination: 155-60 Citation Subset: IM |
Copyright Information:
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Copyright 2010. Published by Elsevier Ireland Ltd. |
Affiliation:
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Department of Radiology and Biomedical Engineering, The Catholic University of Korea, Seoul 420-717, South Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amphetamine-Related Disorders / radionuclide imaging* Brain / blood supply, radionuclide imaging* Brain Mapping Cerebrovascular Circulation / drug effects* Humans Injections, Intravenous Male Methamphetamine / adverse effects* Middle Aged |
| Grant Support | |
ID/Acronym/Agency:
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DA017820/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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537-46-2/Methamphetamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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