Document Detail

In vivo evaluation of porous versus skinned polyurethane-polydimethylsiloxane small diameter vascular grafts.
MedLine Citation:
PMID:  1751244     Owner:  NLM     Status:  MEDLINE    
Two types of spongy polyurethane-polydimethylsiloxane (PU-PDMS) vascular grafts (1.5 mm ID, 450 microns wall thickness) were fabricated with either a skinned (SG) or a porous (PG) luminal surface and an open mesh filamentous external surface by a spraying, phase-inversion technique. Tubular membranes, 15-20 mm in length, were all implanted by the same surgeon as infrarenal aorta replacements in male Sprague-Dawley rats weighing 250-350 g (SG: n = 12, PG: n = 23). The patency rates at 2 weeks and 3 months were 0% (0/7) and 0% (0/1) for SG, 72% (8/11) and 8% (1/12) for PG. Because the wall structure of these grafts was relatively compact and did not provide enough communicating voids, another series of 15 highly porous luminal surface grafts was fabricated with a higher void to material ratio. These grafts (HPG) exhibited a 73% patency at 3 months, with a fully endothelialized surface. The authors conclude that a very open luminal surface structure, and a high wall porosity, are significant factors of graft patency in small diameter vascular prostheses made of a porous material.
T Okoshi; M Goddard; P M Galletti; G Soldani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  ASAIO transactions / American Society for Artificial Internal Organs     Volume:  37     ISSN:  0889-7190     ISO Abbreviation:  ASAIO Trans     Publication Date:    1991 Jul-Sep
Date Detail:
Created Date:  1992-01-29     Completed Date:  1992-01-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8611947     Medline TA:  ASAIO Trans     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  M480-1     Citation Subset:  IM    
Artificial Organ Laboratory, Brown University, Providence, Rhode Island.
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MeSH Terms
Blood Vessel Prosthesis*
Microscopy, Electron, Scanning
Prosthesis Design
Rats, Inbred Strains
Surface Properties
Reg. No./Substance:
0/Dimethylpolysiloxanes; 0/Polyurethanes; 0/Silicones; 63148-62-9/baysilon

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