| In vivo evaluation of porous versus skinned polyurethane-polydimethylsiloxane small diameter vascular grafts. | |
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MedLine Citation:
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PMID: 1751244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two types of spongy polyurethane-polydimethylsiloxane (PU-PDMS) vascular grafts (1.5 mm ID, 450 microns wall thickness) were fabricated with either a skinned (SG) or a porous (PG) luminal surface and an open mesh filamentous external surface by a spraying, phase-inversion technique. Tubular membranes, 15-20 mm in length, were all implanted by the same surgeon as infrarenal aorta replacements in male Sprague-Dawley rats weighing 250-350 g (SG: n = 12, PG: n = 23). The patency rates at 2 weeks and 3 months were 0% (0/7) and 0% (0/1) for SG, 72% (8/11) and 8% (1/12) for PG. Because the wall structure of these grafts was relatively compact and did not provide enough communicating voids, another series of 15 highly porous luminal surface grafts was fabricated with a higher void to material ratio. These grafts (HPG) exhibited a 73% patency at 3 months, with a fully endothelialized surface. The authors conclude that a very open luminal surface structure, and a high wall porosity, are significant factors of graft patency in small diameter vascular prostheses made of a porous material. |
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Authors:
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T Okoshi; M Goddard; P M Galletti; G Soldani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: ASAIO transactions / American Society for Artificial Internal Organs Volume: 37 ISSN: 0889-7190 ISO Abbreviation: ASAIO Trans Publication Date: 1991 Jul-Sep |
Date Detail:
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Created Date: 1992-01-29 Completed Date: 1992-01-29 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8611947 Medline TA: ASAIO Trans Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: M480-1 Citation Subset: IM |
Affiliation:
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Artificial Organ Laboratory, Brown University, Providence, Rhode Island. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Vessel Prosthesis* Dimethylpolysiloxanes* Dogs Microscopy, Electron, Scanning Polyurethanes* Prosthesis Design Rats Rats, Inbred Strains Silicones* Surface Properties |
| Chemical | |
Reg. No./Substance:
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0/Dimethylpolysiloxanes; 0/Polyurethanes; 0/Silicones; 63148-62-9/baysilon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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