Document Detail

In-vivo evaluation of a novel bipolar radiofrequency device for interstitial thermotherapy of liver tumors during normal and interrupted hepatic perfusion.
MedLine Citation:
PMID:  16360176     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Only monopolar systems have thus far been available for radiofrequency ablation of liver tumors, whose application is restricted because of the incalculable energy flow, reduction of electrical tissue conduction, and limited lesion size. The aim of this study was to evaluate a novel internally cooled bipolar radiofrequency application device under in vivo conditions and to compare the effect of this system on lesion size when combined with hepatic arterial microembolization or complete hepatic blood flow occlusion. MATERIALS AND METHODS: In a porcine liver model, RFA (60 W, 12 min) was performed with either normal (n = 12), partially interrupted (arterial microembolization via a hepatic artery catheter n = 12) or completely interrupted hepatic perfusion (Pringle's maneuver, n = 12). RFA parameters (impedance, power output, temperature, applied energy) were determined continuously during therapy. RFA lesions were macroscopically assessed after liver dissection. RESULTS: Bipolar RFA induced clinical relevant ellipsoid thermal lesions without complications. Hepatic inflow occlusion led to a 4.3-fold increase in lesion volume after arterial microembolization and a 5.8-fold increase after complete interruption (7.4 cm(3)versus 31.9 cm(3)versus 42.6 cm(3), P < 0.01). CONCLUSIONS: The novel bipolar RFA device is a safe and effective alternative to monopolar RFA-systems. Interrupting hepatic perfusion significantly increases lesion volumes in bipolar RFA. This beneficial effect can also be achieved in the percutaneous application mode by RFA combined with arterial microembolization via a hepatic artery catheter.
Joerg-P Ritz; Kai S Lehmann; Christoph Isbert; Christoph Reissfelder; Thomas Albrecht; Thomas Stein; Heinz J Buhr
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-12-19
Journal Detail:
Title:  The Journal of surgical research     Volume:  133     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-29     Completed Date:  2006-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  176-84     Citation Subset:  IM    
Department of General, Vascular and Thoracic Surgery, University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany.
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MeSH Terms
Catheter Ablation / instrumentation*,  methods
Embolization, Therapeutic*
Hepatic Artery
Hyperthermia, Induced / instrumentation*,  methods
Liver / blood supply,  surgery
Liver Circulation*
Liver Neoplasms / secondary,  surgery*
Sus scrofa
Reg. No./Substance:

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