Document Detail

In vivo evaluation of a new sealant material on a rat lung air leak model.
MedLine Citation:
PMID:  11745518     Owner:  NLM     Status:  MEDLINE    
The ability of an albumin-based hydrogel sealant (ABHS) to prevent air leakage through the suture line after pulmonary surgery was evaluated by comparison with that of a fibrin glue (FG). As an air-leak model, a rat lung was used in which a standard incision was made and the burst pressure for ABHS and FG was measured. The average burst pressures at time 0 for the FG and ABHS groups were 30.8+/-15.2 and 77.5 +/-19.1 mmHg, respectively. At Day 3, the value of ABHS (76.3 +/- 15.8 mmHg) was still significantly higher (P<0.05) than that of FG (60.0 +/- 21.9 mmHg). At Day 7, no statistical difference was observed between the FG group(71.2 +/- 18.6 mmHg) and the ABHS group(88.8 +/- 11.7 mmHg). Histological examination of the incision at Day 14 revealed that neither sealant was not visible at the incision site, and there was no evidence of adverse tissue reaction. It was concluded that ABHS had good sealing properties and is an alternative to FG for air leakage treatment in pulmonary surgery.
H Kobayashi; T Sekine; T Nakamura; Y Shimizu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of biomedical materials research     Volume:  58     ISSN:  0021-9304     ISO Abbreviation:  J. Biomed. Mater. Res.     Publication Date:  2001  
Date Detail:
Created Date:  2001-12-17     Completed Date:  2002-03-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0112726     Medline TA:  J Biomed Mater Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  658-65     Citation Subset:  IM    
Copyright Information:
Copyright 2001 John Wiley & Sons, Inc.
R&D Department, 3M Health Care Limited, 3-8-8 Minami-Hashimoto Sagamihara Kanagawa, 229-1185 Japan.
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MeSH Terms
Cross-Linking Reagents
Drug Evaluation, Preclinical
Fibrin Tissue Adhesive
Lung / pathology,  surgery*
Lung Injury
Models, Animal
Polyethylene Glycols / therapeutic use*
Rats, Wistar
Serum Albumin / therapeutic use*
Succinates / therapeutic use*
Suture Techniques
Thoracotomy / adverse effects*
Tissue Adhesives / therapeutic use*
Reg. No./Substance:
0/Cross-Linking Reagents; 0/Fibrin Tissue Adhesive; 0/Polyethylene Glycols; 0/Serum Albumin; 0/Succinates; 0/Tissue Adhesives

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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