Document Detail

In vivo evaluation of a new embolic spherical particle (HepaSphere) in a kidney animal model.
MedLine Citation:
PMID:  18167024     Owner:  NLM     Status:  MEDLINE    
HepaSphere is a new spherical embolic material developed in a dry state that absorbs fluids and adapts to the vessel wall, leaving no space between the particle and the arterial wall. The aim of this study was to elucidate the final in vivo size, deformation, final location, and main properties of the particles when reconstituted with two different contrast media (Iodixanol and Ioxaglate) in an animal model. Two sizes of "dry-state" particles (50-100 and 150-200 microm) were reconstituted using both ionic and nonionic contrast media. The mixture was used to partly embolize both kidneys in an animal model (14 pigs). The animals were sacrificed 4 weeks after the procedure and the samples processed. The final size of the particles was 230.2 +/- 62.5 microm for the 50- to 100-microm dry-state particles and 314.4 +/- 71 microm for the 150- to 200-microm dry-state particles. When the contrast medium (ionic versus nonionic) used for the reconstitution was studied to compare (Student's t-test) the final size of the particles, no differences were found (p > 0.05). The mean in vivo deformation for HepaSphere was 17.1% +/- 12.3%. No differences (p > 0.05) were found in the deformation of the particle regarding the dry-state size or the contrast medium (Mann-Whitney test). We conclude that HepaSphere is stable, occludes perfectly, and morphologically adapts to the vessel lumen of the arteries embolized. There is no recanalization of the arteries 4 weeks after embolization. Its final in vivo size is predictable and the particle has the same properties in terms of size and deformation with the two different contrast media (Iodixanol and Ioxaglate).
Esther de Luis; Jose I Bilbao; Jose A García Jalón de Ciércoles; Antonio Martínez-Cuesta; Alba de Martino Rodríguez; María D Lozano
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-01
Journal Detail:
Title:  Cardiovascular and interventional radiology     Volume:  31     ISSN:  1432-086X     ISO Abbreviation:  Cardiovasc Intervent Radiol     Publication Date:    2008 Mar-Apr
Date Detail:
Created Date:  2008-03-18     Completed Date:  2008-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003538     Medline TA:  Cardiovasc Intervent Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  367-76     Citation Subset:  IM    
Department of Radiology, Clínica Universitaria Navarra, Universidad de Navarra, Avda Pio XII 36, Pamplona, 31008, Navarra, Spain.
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MeSH Terms
Acrylates / pharmacology*
Contrast Media
Embolization, Therapeutic
Ioxaglic Acid
Kidney / blood supply*
Particle Size
Polyvinyl Alcohol / pharmacology*
Statistics, Nonparametric
Triiodobenzoic Acids
Reg. No./Substance:
0/Acrylates; 0/Contrast Media; 0/Triiodobenzoic Acids; 59017-64-0/Ioxaglic Acid; 9002-89-5/Polyvinyl Alcohol; 92339-11-2/iodixanol

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