Document Detail

In vivo evaluation of left ventricular function in aged SHR by volume loading and the positive inotropic effect of denopamine.
MedLine Citation:
PMID:  3735807     Owner:  NLM     Status:  MEDLINE    
The positive inotropic effect of denopamine on the hypertrophied heart was studied in 12-months spontaneously hypertensive rats (12-month-SHR) with and without volume loading. Firstly, the influence of volume loading on cardiac function was studied in 12-month-SHR compared with the age-matched normotensive Wistar-Kyoto rats (WKY) and younger WKY (4-month-WKY) as well. Left ventricular end-diastolic pressure (LVEDP) and maximum rate of rise of left ventricular pressure (LV dp/dtmax) were significantly higher in SHR than in WKY and 4-month-WKY. Volume loading (saline, 2 ml/kg/min, i.v., for 10 min) caused a marked increase in LVEDP both in SHR and WKY, but a higher elevation of LVEDP was observed in SHR. LV dp/dtmax, however, was increased in WKY and more markedly in 4-month-WKY, while it was not increased in SHR. Administration of denopamine to SHR at a rate of 1 microgram/kg/min, i.v., for 10 min before and during 10 min of volume loading produced a marked increase in LV dp/dtmax and a significant decrease in LVEDP. Under denopamine infusion, volume loading caused an increase in LV dp/dtmax and produced a LVEDP elevation to a similar level to that of WKY. Denopamine at this dose caused no significant effects on heart rate and mean arterial blood pressure, indicating a selective inotropic action. The present study suggests that functional cardiac reserve is reduced in the aged SHR and that denopamine increases the functional reserve of the hypertrophied heart.
T Ikeo; T Nagao
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  41     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-09-16     Completed Date:  1986-09-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Body Weight
Cardiotonic Agents / pharmacology*
Ethanolamines / pharmacology*
Heart / drug effects,  physiology*
Heart Rate / drug effects
Heart Ventricles / drug effects,  growth & development
Myocardial Contraction / drug effects*
Organ Size
Rats, Inbred SHR
Rats, Inbred WKY
Ventricular Function
Reg. No./Substance:
0/Cardiotonic Agents; 0/Ethanolamines; 71771-90-9/denopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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