Document Detail

In vivo evaluation of alpha(2)-adrenoceptors in cats with idiopathic cystitis.
MedLine Citation:
PMID:  17269887     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the in vivo response of alpha(2)-adrenoceptors to medetomidine administration in cats with feline idiopathic cystitis (FIC) during periods of stress and after environmental enrichment. ANIMALS: 13 cats with FIC and 12 healthy cats. Procedures-Cats were subjected to an acute-onset moderate stressor for 8 days. After stress, 20 microg of medetomidine/kg was administered IM on days 1, 3, and 8. Heart rate, blood pressure, pupil diameter, respiratory rate, and level of sedation were evaluated before and after administration of the drug. After day 8, cats were moved to an enriched environment, and tests were repeated on day 35. RESULTS: Heart rate decreased and pupil diameter increased significantly after medetomidine administration in healthy cats, compared with cats with FIC. Cats with FIC had significantly lower respiratory rates. No significant differences in blood pressure or sedation level were found. CONCLUSIONS AND CLINICAL RELEVANCE: Increased plasma catecholamine concentrations during the enrichment phase, which have been reported elsewhere, may have contributed to the differences in alpha(2)-adrenoceptor responses detected in cats with FIC.
Jodi L Westropp; Philip H Kass; C A Tony Buffington
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  American journal of veterinary research     Volume:  68     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-02     Completed Date:  2007-03-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-7     Citation Subset:  IM    
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology
Cat Diseases / metabolism*
Cystitis / metabolism,  veterinary*
Medetomidine / pharmacology
Receptors, Adrenergic, alpha-2 / metabolism*
Stress, Physiological / physiopathology
Time Factors
Grant Support
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Receptors, Adrenergic, alpha-2; 86347-14-0/Medetomidine

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