Document Detail

In-vivo evaluation of the BioPhysio valve prosthesis in the aortic position.
MedLine Citation:
PMID:  18365577     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM OF THE STUDY: The new BioPhysio aortic prosthesis is a pericardial valve with a flexible stent that can be implanted with a single suture line. The study aim was to evaluate the in-vivo implantation characteristics, preservation of dynamic motion of the aortic root, and hemodynamic performance of this bioprosthesis. METHODS: The BioPhysio valve was implanted, in the aortic position, in 10 young adult male sheep. Transesophageal and intracardiac echocardiography were carried out postoperatively for hemodynamic evaluation. Cineangiography was performed both preoperatively and postoperatively to assess aortic root dynamics and to document the absence of aortic regurgitation. Cardiac output was monitored via a Swan-Ganz catheter, both preoperatively and postoperatively. RESULTS: The BioPhysio valve was implanted with interrupted mattress sutures in seven cases, and with continuous sutures in three cases. At a mean cardiac output of 5.9 l/min, the mean transaortic pressure gradients were 5.93 and 3.6 mmHg for the 19- and 21-mm valves, respectively, and the mean effective orifice areas were 2.08 and 2.65 cm2. Mean dilation of the aortic root, measured as the maximum expansion of the radiopaque frame in systole, was 9.01%. CONCLUSION: The unique flexible stent design of the new BioPhysio valve preserves the dynamic motion of the aortic root, by combining the hemodynamic benefits of stentless valves with the ease of implantation of stented bioprostheses.
Mirko Doss; Petar Risteski; Jeffrey P Wood; Gerhard Wimmer-Greinecker; Anton Moritz
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  The Journal of heart valve disease     Volume:  17     ISSN:  0966-8519     ISO Abbreviation:  J. Heart Valve Dis.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-03-27     Completed Date:  2008-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312096     Medline TA:  J Heart Valve Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  105-9     Citation Subset:  IM    
Department of Thoracic and Cardiovascular Surgery, Johann Wolfgang Goethe University Frankfurt am Main, Germany.
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MeSH Terms
Aortic Valve / radiography,  surgery*,  ultrasonography
Disease Models, Animal
Echocardiography, Transesophageal
Heart Valve Diseases / diagnosis,  physiopathology,  surgery*
Heart Valve Prosthesis*
Heart Valve Prosthesis Implantation / instrumentation*
Prosthesis Design
Suture Techniques / instrumentation
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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