| In vivo electron spin resonance spectroscopy on signal decay of intrastriatal nitroxide radical after acute administration of haloperidol in rats. | |
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MedLine Citation:
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PMID: 10704781 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sequential changes in the electron spin resonance (ESR) signal intensity of nitroxide radical perfused in the striatum of rats treated with haloperidol (HPD) were evaluated using a 700-MHz ESR spectrometer. Nitroxide radical was perfused in the striatum by in vivo microdialysis. Nitroxide used was 3-carbamoyl-2,2,5, 5-tetramethylpyrrolidine-1-oxyl. Following 6-h perfusion of the nitroxide radical by dialysis at the rate of 2 microl/min through the radical introducer that had been stereotaxically implanted in the rat's striatum, HPD or saline was injected intraperitoneally into the rats in the resonator. The sequential changes in the ESR spectrum of the nitroxide radical were then evaluated. Spectra were successively observed in all animals. The half-life, which was estimated on the basis of the exponential decay in signal intensity, was used as a parameter of decay rate of the ESR signal intensity of nitroxide radical. The half-life in the rats injected with HPD was significantly longer than that in controls. This finding suggests that the reducing ability of the striatal extracellular space of a rat acutely treated with HPD was decreased in comparison with that of the control. |
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Authors:
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Y Ueda; H Yokoyama; A Nakajima; H Ohya-Nishiguchi; H Kamada |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brain research bulletin Volume: 51 ISSN: 0361-9230 ISO Abbreviation: Brain Res. Bull. Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-03-24 Completed Date: 2000-03-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 313-7 Citation Subset: IM |
Affiliation:
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Institute for Life Support Technology, Yamagata Technopolis Foundation, Matsuei, Japan. usan@post1.miyazaki-med.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Corpus Striatum / drug effects, metabolism* Cyclic N-Oxides* Dopamine Antagonists / pharmacology* Electron Spin Resonance Spectroscopy Extracellular Space / metabolism Haloperidol / pharmacology* Injections, Intraperitoneal Male Microdialysis Oxidation-Reduction Rats Rats, Wistar Spin Labels* |
| Chemical | |
Reg. No./Substance:
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0/Cyclic N-Oxides; 0/Dopamine Antagonists; 0/Spin Labels; 3229-73-0/3-carbamoyl-2,2,5,5-tetramethyl-3-pyrroline-1-yloxyl; 52-86-8/Haloperidol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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