| In vivo effects of nipecotic acid on levels of extracellular GABA and taurine, and hippocampal excitability. | |
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MedLine Citation:
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PMID: 6738829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of nipecotic acid on the extracellular levels of the putative hippocampal inhibitory transmitters, gamma-aminobutyric acid (GABA) and taurine, and also excitability in the dentate gyrus, were studied in anaesthetised rats using the dialytrode technique. The dentate gyrus was perfused by means of a dialytrode , using Krebs-Ringer bicarbonate or nipecotic acid solutions. Dentate field potentials, evoked by electrical stimulation of the perforant pathway, were recorded. Nipecotic acid drastically elevated the levels of extracellular GABA and taurine and the amplitude of population spikes in the dentate was concomitantly decreased. These results indicate that changes in extracellular levels of endogenous GABA and/or taurine influence the excitability of the hippocampus. |
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Authors:
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J Lerma; O Herreras; A S Herranz; D Munoz; R M del Rio |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuropharmacology Volume: 23 ISSN: 0028-3908 ISO Abbreviation: Neuropharmacology Publication Date: 1984 May |
Date Detail:
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Created Date: 1984-08-01 Completed Date: 1984-08-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0236217 Medline TA: Neuropharmacology Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 595-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Electrophysiology Hippocampus / physiology* Nipecotic Acids / pharmacology* Proline* / analogs & derivatives* Rats Rats, Inbred Strains Taurine / metabolism* gamma-Aminobutyric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Nipecotic Acids; 107-35-7/Taurine; 147-85-3/Proline; 498-95-3/nipecotic acid; 56-12-2/gamma-Aminobutyric Acid; 56879-46-0/homoproline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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