Document Detail

In vivo effects of head-to-tail 3-alkylpiridinium polymers isolated from the marine sponge Raniera sarai.
MedLine Citation:
PMID:  11005659     Owner:  NLM     Status:  MEDLINE    
Water soluble polymeric 3-alkylpyridinium salts (poly APS; MW 18900 and 5520 Da) were isolated from the marine sponge Raniera sarai. In vitro it strongly inhibited acetyl cholinesterase (AChE) from different species (electric eel, horse serum, human erythrocytes). In our experiments the importance of anti AChE activity in the toxin lethality was evaluated. In vivo experiments were performed on male Wistar rats and ECG, blood pressure and breathing pattern were monitored. After i.v. application of lethal doses of the toxin ECG showed signs of hypo perfusion. Arterial blood pressure fell to mid-circulatory pressure, and breathing stopped after a few breaths At sublethal doses the toxin caused an increase of residual volume, prolongation of expiration, and bradycardia. Patho-anatomical examination revealed that the plugs in lung circulation may cause the death of experimental animals due to cardiorespiratory failure.
M Bunc; K Sepcic; T Turk; D Suput
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  440     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  2000  
Date Detail:
Created Date:  2001-01-02     Completed Date:  2001-02-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  R173-4     Citation Subset:  IM    
Department of Pathophysiology, Medical Faculty, Ljubljana, Slovenia.
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MeSH Terms
Blood Pressure / drug effects
Bradycardia / chemically induced
Dose-Response Relationship, Drug
Injections, Intravenous
Kidney / drug effects,  pathology
Lung / drug effects,  pathology
Myocardium / pathology
Polymers / toxicity*
Pyridinium Compounds / toxicity*
Rats, Wistar
Respiration / drug effects
Time Factors
Reg. No./Substance:
0/Polymers; 0/Pyridinium Compounds; 0/poly-APS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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