Document Detail


In vivo effects of defibrotide on platelet c-AMP and blood prostanoid levels.
MedLine Citation:
PMID:  3011617     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients were treated with defibrotide (3 X 200 mg/day) for 7 days. Plasma PGI2 and TXB2 levels were measured by RIA using EDTA-aspisol as anticoagulant and cyclooxygenase inhibitor. Isolated platelet c-AMP levels were also determined by RIA, using EDTA-dipyridamole as anticoagulant and phosphodiesterase inhibitor. Blood PGI2 levels were found to increase significantly upon treatment while the increase in TXB2 levels was not significant. Blood PGI2/TXB2 ratio increased 51%, 30 min after intravenous injection and it remained 28% higher during therapy than the predrug blood level. Significantly higher platelet c-AMP levels were also obtained after the injection of drug (0.02 less than p less than 0.05).
Authors:
G Cizmeci
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Haemostasis     Volume:  16 Suppl 1     ISSN:  0301-0147     ISO Abbreviation:  Haemostasis     Publication Date:  1986  
Date Detail:
Created Date:  1986-06-30     Completed Date:  1986-06-30     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  0371574     Medline TA:  Haemostasis     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  31-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
6-Ketoprostaglandin F1 alpha / blood
Arteriosclerosis / blood*,  drug therapy
Blood Platelets / drug effects*,  metabolism
Cyclic AMP / blood
Fibrinolytic Agents / therapeutic use*
Humans
Malondialdehyde / blood
Platelet Aggregation / drug effects
Polydeoxyribonucleotides / therapeutic use*
Prostaglandins / blood*
Thromboxane B2 / blood
Time Factors
Chemical
Reg. No./Substance:
0/Fibrinolytic Agents; 0/Polydeoxyribonucleotides; 0/Prostaglandins; 438HCF2X0M/defibrotide; 542-78-9/Malondialdehyde; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha; 60-92-4/Cyclic AMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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