Document Detail

In vivo effects of Escherichia coli endotoxemia on diaphragmatic microcirculation in rats.
MedLine Citation:
PMID:  1629076     Owner:  NLM     Status:  MEDLINE    
We investigated the effects of Escherichia coli endotoxin administration on diaphragmatic microcirculation in rats by in vivo videomicroscopy. Rats were allocated into three groups: 1) intravenous inoculation of 10 mg/kg of E. col endotoxin (group E, n = 25), 2) intravenous inoculation of sterile 0.9% NaCl (group C, n = 20), and 3) induction of a controlled hemorrhage by reducing the vascular volume via an arterial catheter (group H, n = 15). Mean blood pressure (BP) and arteriolar diameters were measured at 15-min intervals and capillary perfusion pattern at 30-min intervals for 1 h. BP decreased similarly in groups E and H, whereas it was maintained in group C. Arterioles were classified as second (A2, n = 46), third (A3, n = 22), and fourth (A4, n = 21) order, according to their relative localization in the network. Basal diameters were the same in the three groups: 38.16, 17.33, and 6.80 microns in group C; 38.17, 17.41, and 7.04 microns in group E; and 37.82, 19.19, and 6.99 microns in group H for A2, A3, and A4, respectively. During the observation period, a significant and similar vasoconstriction of A2 arterioles was observed in groups E and H but not in group C. By contrast, in the three groups, no significant changes in diameter were found for the A3 and A4 arterioles. Capillary perfusion was markedly impaired in group E: at 60 min the percentage of non-perfused capillaries was 40.92 +/- 6.65% in group E compared with 21.17 +/- 5.45% in group C (P less than 0.05) and 18.18 +/- 8.11% in group H (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
J Boczkowski; E Vicaut; M Aubier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  72     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-08-19     Completed Date:  1992-08-19     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2219-24     Citation Subset:  IM    
Institute National de la Santé et de la Recherche Médicale U226, Faculté Xavier Bichat, Paris, France.
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MeSH Terms
Arterioles / drug effects,  physiopathology
Bacterial Toxins / toxicity
Capillaries / drug effects,  physiopathology
Diaphragm / blood supply*
Endotoxins / toxicity
Escherichia coli
Hemodynamics / drug effects,  physiology*
Lipopolysaccharides / toxicity
Microcirculation / drug effects,  physiology
Rats, Inbred Strains
Toxemia / physiopathology*
Vasoconstriction / drug effects,  physiology
Reg. No./Substance:
0/Bacterial Toxins; 0/Endotoxins; 0/Lipopolysaccharides

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