Document Detail


In vivo effect of simvastatin on lipoprotein cholesteryl ester metabolism in normocholesterolemic volunteers.
MedLine Citation:
PMID:  2022059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A kinetic study on lipoprotein cholesteryl ester metabolism was carried out in 4 normolipidemic volunteers before and after treatment with simvastatin. They received LDL labelled with 3H-cholesteryl linoleate. A lipoprotein cholesteryl ester model was developed that fit the radioactivity in LDL, HDL and VLDL cholesteryl ester during 24 hours following injection. Before treatment, the model is consistent with previously reported data. Moreover our results suggest that, in normal fasting subjects, the efflux of plasma cholesteryl ester is almost exclusively derived from LDL. Administration of drug decreased LDL cholesteryl ester concentration by 35%. After treatment, the rate constant concerning LDL catabolism was increased by 25% and the model required the existence of a direct removal of VLDL cholesteryl ester (40% of total VLDL turnover). Our results suggest that the reduction in the LDL cholesteryl ester concentration induced by treatment with simvastatin is due to an increase in the uptake of LDL and LDL precursors (VLDL, VLDL remnants) by LDL receptors.
Authors:
T Magot; C L Malmendier; K Ouguerram; J F Lontie; C Lutton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  196     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-06-06     Completed Date:  1991-06-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  59-68     Citation Subset:  IM    
Affiliation:
Laboratoire de Physiologie de la Nutrition, URA DO646 CNRS, Université de Paris-Sud, Orsay, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticholesteremic Agents
Cholesterol Esters / blood*
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Cholesterol, VLDL / blood
Humans
Kinetics
Lipoproteins / blood*
Lovastatin / analogs & derivatives*,  pharmacology
Male
Models, Biological
Simvastatin
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Cholesterol Esters; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Cholesterol, VLDL; 0/Lipoproteins; 75330-75-5/Lovastatin; 79902-63-9/Simvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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