Document Detail

In vivo effect of an immunostimulating bacterial lysate on human B lymphocytes.
MedLine Citation:
PMID:  17026840     Owner:  NLM     Status:  MEDLINE    
The aim of the present study is to investigate in humans the mechanism by which the oral vaccine Polyvalent Mechanical Bacterial Lysate (PMBL) can rapidly mobilize specific immune response and evaluate the efficacy of its immunostimulating activity in preventing recurrent infections of the upper respiratory tract (URTIs) in a group of patients with a medical history of URTI recurrence. Patients received, by sublingual route, PBML, an immunostimulating lysate obtained by mechanical lysis of the most common bacteria responsible for upper respiratory tract infections. The treatment was administered for 10 consecutive days/month for 3 consecutive months. After the end of the treatment period the patients were followed up for an additional 3 months. The frequency of IgM memory B cells and the expression of the activation marker CD25 in peripheral blood lymphocytes were measured using the flow cytometric method before the start and at days 30 and 90 of the treatment cycle. To correlate clinical results to immunological parameters, the patients were monitored at different time-points during the treatment and at the end of follow-up period. The results showed that PMBL exerts a therapeutic and preventing effect in acute and recurrent infections of the upper respiratory tract and that this effect correlated with the activation and enhancement of both IgM memory B lymphocytes (CD24+/CD27+ cells) and IL2 receptor-expressing lymphocytes (CD25+ cells) involved either in humoral or cellular immunity.
G Lanzilli; R Falchetti; A Cottarelli; A Macchi; D Ungheri; M P Fuggetta
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  International journal of immunopathology and pharmacology     Volume:  19     ISSN:  0394-6320     ISO Abbreviation:  Int J Immunopathol Pharmacol     Publication Date:    2006 Jul-Sep
Date Detail:
Created Date:  2006-10-09     Completed Date:  2006-11-27     Revised Date:  2012-06-22    
Medline Journal Info:
Nlm Unique ID:  8911335     Medline TA:  Int J Immunopathol Pharmacol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  551-9     Citation Subset:  IM    
Institute of Neurobiology and Molecular Medicine, National Research Council, Rome, Italy.
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MeSH Terms
Adjuvants, Immunologic / pharmacology*
B-Lymphocytes / drug effects*,  immunology
Cell Extracts / pharmacology*,  therapeutic use
Immunoglobulin M / biosynthesis
Immunologic Memory / drug effects
Interleukin-2 Receptor alpha Subunit / analysis
Middle Aged
Urinary Tract Infections / drug therapy*
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Broncho-Vaxom; 0/Cell Extracts; 0/Immunoglobulin M; 0/Interleukin-2 Receptor alpha Subunit

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