Document Detail

In vivo effect of dietary factors on the molecular action of aflatoxin B1: role of non-nutrient phenolic compounds on the catalytic activity of liver fractions.
MedLine Citation:
PMID:  7772744     Owner:  NLM     Status:  MEDLINE    
Young adult rats were kept on a synthetic diet containing various food associated phenolic compounds each at 0.5% level. The ability of liver microsomes to catalyze reactions of aflatoxin B1 leading to its activation and DNA adduct formation was measured after an experimental feeding period of 3 weeks. A decrease in both activities was observed with several flavonoids (fisetin, kaempferol, morin, naringin and (+/-)catechin), phenolic acids (caffeic acid and chlorogenic acid), other phenolics (eugenol, vanillin) and synthetic phenolic antioxidants butylated hydroxyanisole and butylated hydroxytoluene. Certain phenolics notably naringin, (+/-) catechin, eugenol, vanillin and butylated hydroxyanisole were also found to induce cytosolic glutathione S-transferase activity that stimulated the formation of specific aflatoxin B1-glutathione conjugate. The results emphasize the role of phenolic compounds in the activation and detoxification processes, and hence in modulating the carcinogenicity of aflatoxin B1.
V S Aboobaker; A D Balgi; R K Bhattacharya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  8     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    1994 Nov-Dec
Date Detail:
Created Date:  1995-07-11     Completed Date:  1995-07-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  1095-8     Citation Subset:  IM    
Radiation Biology and Biochemistry Division, Bhabha Atomic Research Centre, Bombay, India.
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MeSH Terms
Aflatoxin B1 / pharmacokinetics,  pharmacology*
Liver / drug effects*,  metabolism
Phenols / pharmacology*
Rats, Wistar
Reg. No./Substance:
0/Phenols; 1162-65-8/Aflatoxin B1

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