Document Detail

In vivo effect of bradykinin during ischemia and reperfusion: improved electrical stability two weeks after myocardial infarction in the pig.
MedLine Citation:
PMID:  1711627     Owner:  NLM     Status:  MEDLINE    
In this study, the effect of bradykinin or saline infusion during ischemia and reperfusion on electrical stability, 2 weeks after myocardial infarction, was assessed. Acute myocardial infarction was induced in 21 pigs by a transluminal occlusion of the left coronary artery with a catheter balloon, inflated for 45 min. Bradykinin was administered by a 30-min infusion that started after 30 min of coronary occlusion and was continued until 15 min after reperfusion. Although creatine kinase levels in bradykinin-treated animals were significantly lower (p less than 0.001), 2 week survival was not different between groups. In survivors, the filtered QRS (ventricular deflection) duration (detected using signal-averaged electrocardiography) was significantly prolonged in saline-treated pigs, whereas in bradykinin-treated pigs this prolongation was prevented. The terminal voltage of the QRS complex was significantly lower in saline-treated pigs than in bradykinin-treated pigs. These two parameters signify an improved electrical stability after bradykinin treatment. Refractory periods in saline-treated hearts were longer than in bradykinin-treated hearts (106 +/- 10% vs. 95 +/- 13%, p less than 0.05). Also, current thresholds in the infarct border zones showed a greater variance in saline-treated hearts (p less than 0.001), pointing toward more tissue heterogeneity of the infarct border zone. Programmed electrical stimulation showed a trend toward reduced inducibility of sustained ventricular tachycardia in bradykinin-treated hearts. Therefore, bradykinin improves electrical stability weeks after experimental myocardial infarction.
T J Tobé; C D de Langen; R A Tio; K J Bel; P H Mook; H Wesseling
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  17     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-07-29     Completed Date:  1991-07-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  600-7     Citation Subset:  IM    
Department of Pharmacology/Clinical Pharmacology, University of Groningen, The Netherlands.
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MeSH Terms
Arrhythmias, Cardiac / chemically induced,  physiopathology
Bradykinin / pharmacology*
Coronary Disease / physiopathology*
Creatine Kinase / metabolism
Hemodynamics / drug effects
Myocardial Infarction / physiopathology*
Myocardial Reperfusion Injury / physiopathology*
Refractory Period, Electrophysiological / drug effects
Reg. No./Substance:
58-82-2/Bradykinin; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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