| In vivo dynamics and distribution of intracerebroventricularly administered gadodiamide, visualized by magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 10218810 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Direct injections into the cerebroventricles have been extensively utilized in neurophysiological studies. Mapping the distribution of injectate after intracerebroventricular injection has been made only by post mortem analysis, and the dynamic distribution of injectate within the brain has not been well characterized. In this report, we apply contrast-enhanced magnetic resonance imaging to study the pharmacokinetics and extent of non-ionic gadodiamide transport into brain tissue in vivo after intracerebroventricular administration. The results indicate that intracerebroventricular injectate travels quickly throughout the ventricular system from the lateral ventricular site of injection to the fourth ventricle and foramina of Luschka and Magendie within 2 min. After this, the signal intensity begins to increase in the periventricular and paraventricular brain parenchyma. Contrast enhancement is visible 2 mm into the brain tissue from the ventricles. Quantitative analysis of the data shows that the transport of gadodiamide across the ependymal layer that lines the cerebrospinal fluid space characterized a rate constant of 0.066+/-0.017 min(-1). These results provide a better understanding of chemical transport and diffusion following direct injection into the cerebroventricles. They provide information on the in vivo dynamics of injectate after intracerebroventricular administration, and show that contrast enhanced magnetic resonance imaging may be used to more precisely define the target sites of chemicals after intracerebroventricular administration into the brain. |
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Authors:
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J D Bui; D R Nammari; D L Buckley; B A Inglis; X S Silver; T H Mareci; M I Phillips |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuroscience Volume: 90 ISSN: 0306-4522 ISO Abbreviation: Neuroscience Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-06-14 Completed Date: 1999-06-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1115-22 Citation Subset: IM |
Affiliation:
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Department of Physiology, Center for Structural Biology, University of Florida, Gainesville 32610-0274, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / anatomy & histology, metabolism* Contrast Media / administration & dosage*, pharmacokinetics* Gadolinium DTPA / administration & dosage*, pharmacokinetics* Injections, Intraventricular Magnetic Resonance Imaging Male Osmolar Concentration Rats Rats, Sprague-Dawley Tissue Distribution / physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL 27334/HL/NHLBI NIH HHS; R01 NS29362/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 122795-43-1/gadodiamide; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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