Document Detail


In vivo dynamic distribution of 131I-glucagon-like peptide-1 (7-36) amide in the rat studied by gamma camera.
MedLine Citation:
PMID:  10382845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The in vivo distribution of glucagon-like peptide-1 (7-36) amide (GLP-1) was studied in a rat model using radiolabeled GLP-1 (131I-GLP-1) depicted by a gamma-camera. The dynamic scan showed a rapid clearance from the blood circulation after an intravenous (i.v.) injection of 131I-GLP-1. After 10 min, the major part of the radioactivity was accumulated in the kidneys, whereas about 9% (of the blood value) was found in the brain. The pharmacokinetic study using 125I-GLP-1 demonstrated a rapid elimination from plasma, with a half-life of 3.3 +/- 0.6 min, a clearance of 117 +/- 15 mL/min, and a distribution volume of 557 +/- 61 mL. The elimination half-lives for the intact 125I-GLP-1 in lungs and kidneys were determined to 3.7 and 3.9 min, respectively. The metabolite GLP-1 (9-36) amide was followed in blood, lung, and kidney. All other organs assumed to contain low molecular weight fragments of GLP-1. The present study suggest that GLP-1 and/or its labeled metabolites cross the blood-brain barrier. Also the kidney plays an essential role in GLP-1 elimination after an i.v. administration, which can be of clinical interest especially in patients with kidney insufficiency who are treated with GLP-1.
Authors:
M Hassan; A Eskilsson; C Nilsson; C Jonsson; H Jacobsson; E Refai; S Larsson; S Efendic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nuclear medicine and biology     Volume:  26     ISSN:  0969-8051     ISO Abbreviation:  Nucl. Med. Biol.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-08-05     Completed Date:  1999-08-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9304420     Medline TA:  Nucl Med Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  413-20     Citation Subset:  IM    
Affiliation:
Karolinska Pharmacy, Stockholm, Sweden. hassan@algonet.se
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / metabolism
Gamma Cameras
Glucagon
Glucagon-Like Peptide 1
Glucagon-Like Peptides
Iodine Radioisotopes / diagnostic use*
Male
Metabolic Clearance Rate
Peptide Fragments / pharmacokinetics*
Rats
Rats, Sprague-Dawley
Tissue Distribution
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Peptide Fragments; 119637-73-9/glucagon-like peptide 1 (7-36)amide; 62340-29-8/Glucagon-Like Peptides; 89750-14-1/Glucagon-Like Peptide 1; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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