| In vivo dimensional response of airways of different size to transpulmonary pressure. | |
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MedLine Citation:
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PMID: 1150587 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied four supine dogs that were anesthetized with pentobarbital, intubated, and ventilated with a piston pump. The dimensional response of central (CAW) (greater than 2 mm diam) and peripheral airways (PAW) (smaller than 2 mm diam) to changes in transpulmonary pressure (Ptp) was determined by progressive increments in tidal volume (VT). A specially designed electronics relay circuit permitted this relationship to be obtained for points of no flow during tidal volume breathing: i.e., preinspiration (FRC); end inspiration (FRC + VT). The airways were dusted with powdered tantalum. Six airway divisions were identified: four CAW: trachea, main stem, lobar, segmental; and two PAW: subsegmental, and lobular. AP and lateral roentgenograms were obtained by standard technics and primary magnification (mag factor 2). Airway diameters were plotted as a function of transpulmonary pressure between 3 and 26 cmH2O with the diameter at total lung capacity expressed as 100%. The data show that: 1) there is significant distensibility above 5 cmH2O for all airways from the trachea to the lobular airways; 2) that the pressure-diameter plot is a linear plot for each airway from 3 to 26 cmH2O with R values between 0.846 and 0.957; 3) the peripheral lobular airways are more distensible than the central airways (P smaller than 0.05). We attribute the difference in distensibility of the peripheral lobular airways to their lack of cartilaginous support, and their decreased muscular support when compared to the CAW. |
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Authors:
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G M Tisi; V D Minh; P J Friedman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology Volume: 39 ISSN: 0021-8987 ISO Abbreviation: J Appl Physiol Publication Date: 1975 Jul |
Date Detail:
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Created Date: 1975-11-05 Completed Date: 1975-11-05 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0376576 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 23-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Airway Resistance Animals Dogs Functional Residual Capacity Lung / anatomy & histology, physiology, radiography Lung Compliance Pressure Respiratory Physiological Phenomena* Tantalum / diagnostic use Tidal Volume Trachea / anatomy & histology, physiology |
| Chemical | |
Reg. No./Substance:
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7440-25-7/Tantalum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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