| In vivo deformation of the human abdominal aorta and common iliac arteries with hip and knee flexion: implications for the design of stent-grafts. | |
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MedLine Citation:
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PMID: 19842734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To quantify in vivo deformations of the abdominal aorta and common iliac arteries (CIAs) caused by musculoskeletal motion. METHODS: Seven healthy subjects (age 34+/-11 years, range 24-50) were imaged in the supine and fetal positions (hip flexion angle 134.0 degrees +/-9.7 degrees ) using contrast-enhanced magnetic resonance angiography. Longitudinal strain, twisting, and curvature change of the infrarenal aorta and CIAs were computed. The angle between the left and right CIAs and translation of the arteries were also computed. RESULTS: Maximal hip flexion induced shortening (5.2%+/-4.6%), twisting (0.45+/-0.27 degrees /mm), and curvature changes (0.015+/-0.007 mm(-1)) of the CIAs. The angle between the CIAs increased by 17.6 degrees +/-8.6 degrees . The iliac arteries moved predominantly in the superior direction relative to the aortic bifurcation, which would induce compression and bending, thus increasing curvature and angle between the CIAs. The abdominal aorta also exhibited shortening (2.9%+/-2.1%) and twisting (0.07+/-0.05 degrees /mm) deformation associated with the hip flexion. CONCLUSION: Although this study was limited to a few healthy young adults, musculoskeletal motion, specifically hip flexion, caused significant in vivo morphological changes (shortening, twisting, and bending) of the arteries. Predominant superior translation of the CIAs was observed, which suggests that preclinical testing of cyclic superior-inferior translational motion may aid in predicting stent-graft fractures. In turn, stent-graft design could be improved, decreasing overall stent-graft-related complications. |
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Authors:
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Gilwoo Choi; Lewis K Shin; Charles A Taylor; Christopher P Cheng |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists Volume: 16 ISSN: 1545-1550 ISO Abbreviation: J. Endovasc. Ther. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-21 Completed Date: 2010-01-07 Revised Date: 2013-05-31 |
Medline Journal Info:
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Nlm Unique ID: 100896915 Medline TA: J Endovasc Ther Country: United States |
Other Details:
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Languages: eng Pagination: 531-8 Citation Subset: IM |
Affiliation:
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Department of Mechanical Engineering, Stanford University, Stanford, California 94305-5431, USA. giroo@stanford.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aorta, Abdominal / anatomy & histology* Biomechanics Blood Vessel Prosthesis* Computer-Aided Design Female Hip Joint / physiology* Humans Iliac Artery / anatomy & histology* Image Interpretation, Computer-Assisted Imaging, Three-Dimensional Knee Joint / physiology* Magnetic Resonance Angiography* Male Middle Aged Models, Cardiovascular Posture* Prosthesis Design Prosthesis Failure Range of Motion, Articular Stents* Stress, Mechanical Supine Position Torsion, Mechanical Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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P41 RR09784/RR/NCRR NIH HHS; U54 GM072970/GM/NIGMS NIH HHS |
| Comments/Corrections | |
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