| In vivo decomposition of phosphoserine and serine in noncollagenous protein from human dentin. | |
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MedLine Citation:
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PMID: 3926273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HCl-soluble proteins in human dentin ranging in age from 3 to 45 years exhibit amino acid compositional changes consistent with beta-elimination and hydrolysis of phosphoserine as well as dehydration and aldol cleavage of serine. This is the first evidence of nonenzymatic mechanisms for in vivo degradation of hydroxy and substituted hydroxy amino acids in dentin. Decomposition of phosphoseryl residues reduces the calcium-binding capacity of phosphoproteins. Elimination and dehydration reactions can produce variability in molecular weight. The rates of decomposition may be rapid enough to cause the heterogeneity or "maturational" degradation seen in dentin phosphoproteins during mineralization. |
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Authors:
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P M Masters |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Calcified tissue international Volume: 37 ISSN: 0171-967X ISO Abbreviation: Calcif. Tissue Int. Publication Date: 1985 May |
Date Detail:
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Created Date: 1985-09-16 Completed Date: 1985-09-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7905481 Medline TA: Calcif Tissue Int Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 236-41 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aspartic Acid / metabolism Child, Preschool Dentin / metabolism* Humans Isoelectric Point Kinetics Phosphoproteins / metabolism* Serine / metabolism Stereoisomerism |
| Grant Support | |
ID/Acronym/Agency:
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DE06896/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Phosphoproteins; 56-45-1/Serine; 56-84-8/Aspartic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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