Document Detail

In vivo conversion of adult α-cells into β-like cells: a new research avenue in the context of type 1 diabetes.
MedLine Citation:
PMID:  21824256     Owner:  NLM     Status:  In-Data-Review    
Type 1 diabetes is caused by the loss of insulin-producing β-cells as a result of an autoimmune condition. Despite current therapeutic approaches aimed at restoring the insulin supply, complications caused by variations in glycaemia may still arise with age. There is therefore mounting interest in the establishment of alternative therapies. Most current approaches consist in designing rational protocols for in vitro or in vivo cell differentiation/reprogramming from a number of cell sources, including stem, progenitor or differentiated cells. Towards this ultimate goal, it is clear that we need to gain further insight into the interplay between signalling events and transcriptional networks that act in concert throughout pancreatic morphogenesis. This short review will therefore focus on the main events underlying pancreatic development with particular emphasis on the genetic determinants implicated, as well as on the relatively new concept of endocrine cell reprogramming, that is the conversion of pancreatic α-cells into cells displaying a β-cell phenotype.
M Courtney; A Pfeifer; K Al-Hasani; E Gjernes; A Vieira; N Ben-Othman; P Collombat
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diabetes, obesity & metabolism     Volume:  13 Suppl 1     ISSN:  1463-1326     ISO Abbreviation:  Diabetes Obes Metab     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-08-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883645     Medline TA:  Diabetes Obes Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  47-52     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Inserm U636, Diabetes Genetics Team, Nice, France Université de Nice-Sophia Antipolis, Laboratoire de Génétique du Développement Normal et Pathologique, Nice, France.
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