| In-vivo concentrations of inhibins, activin A and follistatin in human early pregnancy. | |
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MedLine Citation:
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PMID: 15169590 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aims of this study were to investigate the relationship between inhibins, activin A and follistatin in first trimester fetal fluids, maternal serum, placenta and decidua, and to investigate if these hormones are present in the circulation of the early second trimester human fetus. Amniotic and coelomic fluid, maternal serum, placental villi and decidual tissue were obtained from normal pregnancies at 8-12 weeks. Fetal blood by cardiocentesis and maternal blood were collected at 14-16 weeks gestation. Placental extracts had higher concentrations of inhibins, activin A and follistatin compared with decidual extracts. In the second trimester, inhibins and follistatin were detectable in fetal blood at 14-16 weeks gestation. Maternal serum concentrations of inhibin A (P < 0.001) and follistatin (P < 0.05) were significantly higher than fetal serum whereas inhibin B (P < 0.01) and pro-alpha C concentrations (P < 0.001) were higher in fetal serum. Inhibin B concentrations were also higher in male fetal serum samples that had higher concentrations of testosterone. The presence of all molecular forms of inhibins, activin A and follistatin in the first trimester fetal fluids, placental and decidual extracts in the first trimester confirms other reports. In the second trimester, high concentrations of inhibin B with testosterone in the fetal circulation indicate that these hormones may interact in the development of the male fetal gonads. |
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Authors:
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S Muttukrishna; E Jauniaux; H McGarrigle; N Groome; C H Rodeck |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Reproductive biomedicine online Volume: 8 ISSN: 1472-6483 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-05-31 Completed Date: 2004-07-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: England |
Other Details:
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Languages: eng Pagination: 712-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, RFUC Medical School, 86-96 Chenies Mews, London WC1E 6HX, UK. s.muttukrishna@ucl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activins
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blood* Amniotic Fluid / metabolism* Female Fetus / metabolism Follistatin / blood* Humans Inhibin-beta Subunits / blood* Inhibins / blood* Male Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second Protein Precursors / blood Testosterone / blood |
| Chemical | |
Reg. No./Substance:
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0/Follistatin; 0/Protein Precursors; 0/activin A; 0/inhibin A; 0/inhibin B; 0/inhibin-alpha subunit precursor; 104625-48-1/Activins; 57285-09-3/Inhibins; 58-22-0/Testosterone; 93443-12-0/Inhibin-beta Subunits |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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