| In vivo comparison of a polymer-free biolimus A9-eluting stent with a biodegradable polymer-based biolimus a9 eluting stent and a bare metal stent in balloon denuded and radiated hypercholesterolemic rabbit iliac arteries. | |
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MedLine Citation:
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PMID: 22105925 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: To evaluate the effect of a polymer-free Biolimus A9-eluting stent [BioFreedom™ (BF)], compared with that of a biodegradable polymer-based Biolimus A9-eluting stent [BioMatrix Flex™ (BMF)] and a bare metal stent (BMS) in balloon denuded and radiated hypercholesterolemic rabbit iliac arteries. METHODS: Rabbits were fed with 1% cholesterol diet (n=14) for 14 days, both iliac arteries were balloon denuded and radiated, and then rabbits were switched to 0.15% cholesterol diet. After four weeks, BF (n=8), BMF (n=8), and BMS (n=8) were deployed in denuded and radiated areas. Four weeks later animals were euthanized, arterial segments were processed for morphometry. RESULTS: The neointimal area in vessels implanted with BF stents was significantly less than that seen in vessels implanted with BMS (0.90 mm(2) ± 0.14 vs. 1.29 mm(2) ± 0.23, p <0.01). Percent fibrin and fibrin score were higher with BMF stents compared to BMS (p <0.03 and <0.04) and giant cell number was significantly higher with both BMF and BF stents (p <0.01 for both). Percent endothelialization was significantly higher and % uncovered struts were lower with BMS compared to either BMF or BF stents (p <0.05 for both). CONCLUSION: The present study demonstrates that compared to BMS, BF stents significantly decreased neointimal hyperplasia. © 2011 Wiley-Liss, Inc. |
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Authors:
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Ron Waksman; Rajbabu Pakala; Richard Baffour; Rufus Seabron; David Hellinga; Rosanna Chan; Shih-Horng Su; Frank Kolodgie; Renu Virmani |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-22 |
Journal Detail:
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Title: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Volume: - ISSN: 1522-726X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100884139 Medline TA: Catheter Cardiovasc Interv Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Cardiovascular Research Institute, Washington Hospital Center, Washington, DC, USA. ron.waksman@medstar.net. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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