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In vivo comparison of a polymer-free biolimus A9-eluting stent with a biodegradable polymer-based biolimus a9 eluting stent and a bare metal stent in balloon denuded and radiated hypercholesterolemic rabbit iliac arteries.
MedLine Citation:
PMID:  22105925     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: To evaluate the effect of a polymer-free Biolimus A9-eluting stent [BioFreedom™ (BF)], compared with that of a biodegradable polymer-based Biolimus A9-eluting stent [BioMatrix Flex™ (BMF)] and a bare metal stent (BMS) in balloon denuded and radiated hypercholesterolemic rabbit iliac arteries. METHODS: Rabbits were fed with 1% cholesterol diet (n=14) for 14 days, both iliac arteries were balloon denuded and radiated, and then rabbits were switched to 0.15% cholesterol diet. After four weeks, BF (n=8), BMF (n=8), and BMS (n=8) were deployed in denuded and radiated areas. Four weeks later animals were euthanized, arterial segments were processed for morphometry. RESULTS: The neointimal area in vessels implanted with BF stents was significantly less than that seen in vessels implanted with BMS (0.90 mm(2) ± 0.14 vs. 1.29 mm(2) ± 0.23, p <0.01). Percent fibrin and fibrin score were higher with BMF stents compared to BMS (p <0.03 and <0.04) and giant cell number was significantly higher with both BMF and BF stents (p <0.01 for both). Percent endothelialization was significantly higher and % uncovered struts were lower with BMS compared to either BMF or BF stents (p <0.05 for both). CONCLUSION: The present study demonstrates that compared to BMS, BF stents significantly decreased neointimal hyperplasia. © 2011 Wiley-Liss, Inc.
Authors:
Ron Waksman; Rajbabu Pakala; Richard Baffour; Rufus Seabron; David Hellinga; Rosanna Chan; Shih-Horng Su; Frank Kolodgie; Renu Virmani
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-22
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  -     ISSN:  1522-726X     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Affiliation:
Cardiovascular Research Institute, Washington Hospital Center, Washington, DC, USA. ron.waksman@medstar.net.
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