| In vivo cholesterol synthesis by the rat digestive tract. I. A topological study. | |
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MedLine Citation:
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PMID: 4048647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats were fed a semi-purified diet containing 0.5% cholesterol; cholesterogenesis was measured in vivo 70 min after [1-14C]-acetate or tritiated water was incorporated into the gastrointestinal tract sterols. The results were qualitatively similar with the two precursors. Cholesterol synthesis was preponderant in the small intestine and mainly occurred in its mucosa with a decreasing biosynthetic gradient from the duodenum to the distal ileum. The gradient of cholesterogenesis decreased from the crypt cells to the apical cells in all segments of the intestine studied. |
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Authors:
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M Perrodin; C Lutton |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Reproduction, nutrition, development Volume: 25 ISSN: 0181-1916 ISO Abbreviation: Reprod Nutr Dev Publication Date: 1985 |
Date Detail:
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Created Date: 1985-11-04 Completed Date: 1985-11-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8005903 Medline TA: Reprod Nutr Dev Country: FRANCE |
Other Details:
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Languages: eng Pagination: 647-57 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acid Acetic Acids / metabolism Animals Cecum / metabolism Cholesterol / biosynthesis*, blood Colon / metabolism Digestive System / metabolism* Duodenum / metabolism Ileum / metabolism Intestinal Mucosa / metabolism Jejunum / metabolism Liver / metabolism Male Rats Rats, Inbred Strains Stomach / metabolism Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Acetic Acids; 57-88-5/Cholesterol; 64-19-7/Acetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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