Document Detail

In vivo changes in canine ventricular cardiac conduction during halothane anesthesia.
MedLine Citation:
PMID:  7189379     Owner:  NLM     Status:  MEDLINE    
Changes in the ventricular conduction system associated with halothane anesthesia were investigated by direct methods of His bundle recording, pacing, and premature stimulation in a canine model. In eight animals a change from 1.5% to 2.4% halothane concentrations was associated with significant prolongation of epicardial activation times by an average of 2.4 and 2.9 msec during atrial and His bundle paced rhythms, respectively. Ventricular functional refractory periods decreased significantly by an average of 7.3 msec, the effective refractory period of the ventricular conduction system did not system did not change, and epicardial conduction delays at the effective refractory period decreased. In six other animals the addition of 1.5% halothane to basal thipental anesthesia was not associated with prolongation of epicardial activation times or decreased ventricular functional refractory periods. However, the effective refractory period of the ventricular conduction system significantly decreased by an average of 9.1 msec, and epicardial conduction delays at the effective refractory period significantly increased by an average of 9.6 msec. A change in halothane concentrations from 1.5% to 2.4% is associated with depression of ventricular conduction and shortened duration of refractory periods in the ventricular conduction system in vivo in a manner consistent with the reported actions of halothane on Purkinje fibers in vitro.
L A Turner; E J Zuperku; R V Purtock; J P Kampine
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  59     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-06-25     Completed Date:  1980-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  327-34     Citation Subset:  AIM; IM    
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MeSH Terms
Bundle of His / drug effects
Cardiac Pacing, Artificial
Halothane / pharmacology*
Heart Conduction System / drug effects*
Heart Ventricles
Time Factors
Reg. No./Substance:
151-67-7/Halothane; 76-75-5/Thiopental

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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