Document Detail


In vivo bioprinting for computer- and robotic-assisted medical intervention: preliminary study in mice.
MedLine Citation:
PMID:  20811116     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present the first attempt to apply bioprinting technologies in the perspective of computer-assisted medical interventions. A workstation dedicated to high-throughput biological laser printing has been designed. Nano-hydroxyapatite (n-HA) was printed in the mouse calvaria defect model in vivo. Critical size bone defects were performed in OF-1 male mice calvaria with a 4 mm diameter trephine. Prior to laser printing experiments, the absence of inflammation due to laser irradiation onto mice dura mater was shown by means of magnetic resonance imaging. Procedures for in vivo bioprinting and results obtained using decalcified sections and x-ray microtomography are discussed. Although heterogeneous, these preliminary results demonstrate that in vivo bioprinting is possible. Bioprinting may prove to be helpful in the future for medical robotics and computer-assisted medical interventions.
Authors:
Virginie Keriquel; Fabien Guillemot; Isabelle Arnault; Bertrand Guillotin; Sylvain Miraux; Joëlle Amédée; Jean-Christophe Fricain; Sylvain Catros
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-10
Journal Detail:
Title:  Biofabrication     Volume:  2     ISSN:  1758-5090     ISO Abbreviation:  Biofabrication     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-09-02     Completed Date:  2010-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101521964     Medline TA:  Biofabrication     Country:  England    
Other Details:
Languages:  eng     Pagination:  014101     Citation Subset:  IM    
Affiliation:
INSERM, U577, Bordeaux, F-33076 France and Université Victor Segalen Bordeaux 2, UMR-S577 Bordeaux, F-33076 France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biotechnology / methods*
Bone Substitutes / therapeutic use
Brain / radiation effects
Computer-Aided Design
Durapatite / therapeutic use
Histocytochemistry
Male
Mice
Nanoparticles / therapeutic use
Robotics / methods*
Skull / injuries,  radiography
Skull Fractures / therapy*
Therapy, Computer-Assisted / methods*
Tissue Engineering / methods*
X-Ray Microtomography
Chemical
Reg. No./Substance:
0/Bone Substitutes; 1306-06-5/Durapatite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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