Document Detail


In vivo biological response to vitamin E and vitamin-E-doped polyethylene.
MedLine Citation:
PMID:  21084577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Cross-linking has decreased the wear of ultra-high molecular weight polyethylene, a cause of osteolysis leading to total joint replacement failure. Compared with melting or annealing, doping cross-linked ultra-high molecular weight polyethylene with vitamin E stabilizes free radicals from irradiation while maintaining mechanical properties and wear resistance. This study was done to determine the local tissue effects of free vitamin E and vitamin E eluted from ultra-high molecular weight polyethylene implants in the joint space.
METHODS: Three studies were performed. First, pure vitamin E and solubilized vitamin E were injected into rabbit knees to simulate vitamin-E elution from radiation cross-linked ultra-high molecular weight polyethylene; second, vitamin-E-doped, irradiated ultra-high molecular weight polyethylene plugs were implanted into dorsal subcutaneous pouches of rabbits to determine the local effects of vitamin-E elution from radiation cross-linked ultra-high molecular weight polyethylene; and, third, two groups of vitamin-E-doped, irradiated acetabular liners (high surface and uniform vitamin-E concentration profiles) were compared with undoped, control ultra-high molecular weight polyethylene liners in a canine model of total hip replacement to determine the effect of possible vitamin-E elution on bone ingrowth and the local tissue response to it in a load-bearing environment.
RESULTS: Injection of solubilized vitamin E resulted in histologically normal surrounding soft tissue at both two and twelve-week follow-up intervals, while injection of pure vitamin E resulted in acute and chronic inflammation at the time of the two-week follow-up. Both control and vitamin-E-doped subcutaneous plugs showed inflammation associated with surgery at two weeks of follow-up, but showed stable fibrous encapsulation without inflammation at twelve weeks of follow-up. In the canine total hip replacement model, there was no qualitative difference in local tissue appearance and no significant difference in the percent bone ingrowth and the percent bone density between the control and vitamin-E groups.
CONCLUSIONS: These investigations showed that vitamin-E-doped ultra-high molecular weight polyethylene plugs and total hip replacement components are well tolerated in both a small and a large-animal model with no observed adverse effects on the surrounding tissues at twelve weeks of follow-up.
Authors:
Bryan T Jarrett; Jennifer Cofske; Andrew E Rosenberg; Ebru Oral; Orhun Muratoglu; Henrik Malchau
Related Documents :
21468777 - Short-term outcome of finger joint synovectomy in rheumatoid arthritis.
20011097 - Brigham fracture intervention team initiatives for hospital patients with hip fractures...
21440827 - Onlay and inlay bone grafts with platelet-rich plasma: histologic evaluations from huma...
21190557 - Early decrements in bone density after completion of neoadjuvant chemotherapy in pediat...
19098577 - Multivectorial, external halo-assisted midface distraction in patients with severe hypo...
24283757 - Increased risk for bone loss in women with systemic sclerosis: a comparative study with...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of bone and joint surgery. American volume     Volume:  92     ISSN:  1535-1386     ISO Abbreviation:  J Bone Joint Surg Am     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-18     Completed Date:  2010-12-21     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  0014030     Medline TA:  J Bone Joint Surg Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2672-81     Citation Subset:  AIM; IM    
Affiliation:
Harris Orthopaedic Biomechanics and Biomaterials Laboratory, Massachusetts General Hospital, 1125 Gray/Jackson, 55 Fruit Street, Boston, MA 02115, USA. bjarrett@partners.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Arthroplasty, Replacement, Hip / adverse effects,  methods*
Biopsy, Needle
Disease Models, Animal
Dogs
Drug Carriers*
Female
Immunohistochemistry
Injections, Intralesional
Knee Joint / drug effects*,  pathology,  surgery
Male
Materials Testing*
Osteolysis / etiology,  prevention & control*
Polyethylenes*
Prostheses and Implants* / adverse effects
Prosthesis Design
Prosthesis Failure
Rabbits
Random Allocation
Risk Factors
Treatment Outcome
Vitamin E / administration & dosage*
Chemical
Reg. No./Substance:
0/Drug Carriers; 0/Polyethylenes; 0/ultra-high molecular weight polyethylene; 1406-18-4/Vitamin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical and radiographic results of metal-on-metal hip resurfacing with a minimum ten-year follow-u...
Next Document:  Local treatment of meniscal lesions with vascular endothelial growth factor.