| In vivo biological potency of rat and human growth hormone-releasing factor and fragments of human growth hormone-releasing factor. | |
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MedLine Citation:
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PMID: 6414471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The biological potency of the synthetic replicates of three peptides isolated from a human pancreatic tumor with growth hormone releasing activity and rat hypothalamic growth hormone-releasing factor was evaluated in conscious freely-moving rats and anesthetized rats. All 4 peptides are equipotent on a molar basis in their ability to stimulate GH secretion. Studies with synthetic fragments of the human derived material indicated that the amino-terminal amino acid is required for activity. Deletion of as many as 13 amino acids from the carboxy-terminal failed to decrease GH-releasing activity; however, deletion of 16 amino acids resulted in a significant decrease and deletion of 20 amino acids resulted in complete loss of bioactivity. |
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Authors:
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W B Wehrenberg; N Ling |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 115 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1983 Sep |
Date Detail:
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Created Date: 1983-11-23 Completed Date: 1983-11-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 525-30 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Growth Hormone / blood Growth Hormone-Releasing Hormone / pharmacology* Humans Peptide Fragments / pharmacology* Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
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AM-18811/AM/NIADDK NIH HHS; HD-09690/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 9002-72-6/Growth Hormone; 9034-39-3/Growth Hormone-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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