Document Detail


In vivo biological potency of rat and human growth hormone-releasing factor and fragments of human growth hormone-releasing factor.
MedLine Citation:
PMID:  6414471     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The biological potency of the synthetic replicates of three peptides isolated from a human pancreatic tumor with growth hormone releasing activity and rat hypothalamic growth hormone-releasing factor was evaluated in conscious freely-moving rats and anesthetized rats. All 4 peptides are equipotent on a molar basis in their ability to stimulate GH secretion. Studies with synthetic fragments of the human derived material indicated that the amino-terminal amino acid is required for activity. Deletion of as many as 13 amino acids from the carboxy-terminal failed to decrease GH-releasing activity; however, deletion of 16 amino acids resulted in a significant decrease and deletion of 20 amino acids resulted in complete loss of bioactivity.
Authors:
W B Wehrenberg; N Ling
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  115     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  525-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Growth Hormone / blood
Growth Hormone-Releasing Hormone / pharmacology*
Humans
Peptide Fragments / pharmacology*
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
AM-18811/AM/NIADDK NIH HHS; HD-09690/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Peptide Fragments; 9002-72-6/Growth Hormone; 9034-39-3/Growth Hormone-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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