| In vivo biocompatibility and mechanical properties of porous zein scaffolds. | |
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MedLine Citation:
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PMID: 17582490 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In our previous study, a three-dimensional zein porous scaffold with a compressive Young's modulus of up to 86.6+/-19.9 MPa and a compressive strength of up to 11.8+/-1.7 MPa was prepared, and was suitable for culture of mesenchymal stem cells (MSCs) in vitro. In this study, we examined its tissue compatibility in a rabbit subcutaneous implantation model; histological analysis revealed a good tissue response and degradability. To improve its mechanical property (especially the brittleness), the scaffolds were prepared using the club-shaped mannitol as the porogen, and stearic acid or oleic acid was added. The scaffolds obtained had an interconnected tubular pore structure, 100-380 microm in pore size, and about 80% porosity. The maximum values of the compressive strength and modulus, the tensile strength and modulus, and the flexural strength and modulus were obtained at the lowest porosity, reaching 51.81+/-8.70 and 563.8+/-23.4 MPa; 3.91+/-0.86 and 751.63+/-58.85 MPa; and 17.71+/-3.02 and 514.39+/-19.02 MPa, respectively. Addition of 15% stearic acid or 20% oleic acid did not affect the proliferation and osteogenic differentiation of MSCs, and a successful improvement of mechanical properties, especially the brittleness of the zein scaffold could be achieved. |
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Authors:
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Hua-Jie Wang; Sheng-Ju Gong; Zhi-Xin Lin; Jian-Xi Fu; Song-Tao Xue; Jing-Chun Huang; Jin-Ye Wang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-19 |
Journal Detail:
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Title: Biomaterials Volume: 28 ISSN: 0142-9612 ISO Abbreviation: Biomaterials Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-07-19 Completed Date: 2007-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: England |
Other Details:
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Languages: eng Pagination: 3952-64 Citation Subset: IM |
Affiliation:
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College of Life Science and Biotechnology, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials / chemistry*, pharmacology* Elasticity Materials Testing Mechanics Porosity Rabbits Skin / cytology*, drug effects* Tensile Strength Zein / chemistry*, pharmacology*, ultrastructure |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 9010-66-6/Zein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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