Document Detail


In vivo binding of [3H]ketanserin on serotonin S2-receptors in rat brain.
MedLine Citation:
PMID:  7117369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In vivo binding of [3H]ketanserin was studied in various brain regions in rats. After i.v. injection of [3H]ketanserin (5 micrograms . kg-1), the highest labelling was found in the frontal cortex. Brain disposition of labelled drug correlated with the distribution of serotonin S2-receptors detected in vitro. The binding was saturable in the serotonergic areas but not in the cerebellum. Various drugs were tested for their ability to displace or to prevent [3H]ketanserin binding: these results were then compared to those obtained with [3H]spiperone in the frontal cortex. Although [3H]spiperone can be used to differentiate the affinity of a drug for serotonin (frontal cortex) and dopamine (striatum) receptors, the great advantage of [3H]ketanserin is that it labels serotonin S2-receptors exclusively.
Authors:
P M Laduron; P F Janssen; J E Leysen
Related Documents :
6821889 - Inhibition of specific binding of [3h]phorbol-12,13-dipropionate to an epidermal fracti...
6640329 - [3h]r05-4864 and [3h]flunitrazepam binding in kainate-lesioned rat striatum and in temp...
6248119 - Effects of local anesthetics on guanyl nucleotide modulation of the catecholamine-sensi...
2747629 - Development of a photoaffinity ligand for octopamine receptors.
8747159 - Nuclear [3h]naloxone binding in rat hypothalamus.
1848629 - Gamma-aminobutyric acida receptor heterogeneity in rat central nervous system: studies ...
10908659 - Specific binding sites for alcohols and anesthetics on ligand-gated ion channels.
15313199 - Anthrax toxin complexes: heptameric protective antigen can bind lethal factor and edema...
15696369 - Evolution of abca4 proteins in vertebrates.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  81     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  43-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Brain / metabolism*
Ketanserin
Male
Piperidines / metabolism*
Rats
Rats, Inbred Strains
Receptors, Serotonin / metabolism*
Serotonin Antagonists / metabolism*
Spiperone / metabolism
Tritium
Chemical
Reg. No./Substance:
0/Piperidines; 0/Receptors, Serotonin; 0/Serotonin Antagonists; 10028-17-8/Tritium; 74050-98-9/Ketanserin; 749-02-0/Spiperone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Inhibition of efferent sympathetic nerve activity by centrally administered paraoxon in the cat.
Next Document:  Serotonin-like actions of quipazine and CPP on spinal motoneurones.