| In vivo binding of [3H]ketanserin on serotonin S2-receptors in rat brain. | |
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MedLine Citation:
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PMID: 7117369 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In vivo binding of [3H]ketanserin was studied in various brain regions in rats. After i.v. injection of [3H]ketanserin (5 micrograms . kg-1), the highest labelling was found in the frontal cortex. Brain disposition of labelled drug correlated with the distribution of serotonin S2-receptors detected in vitro. The binding was saturable in the serotonergic areas but not in the cerebellum. Various drugs were tested for their ability to displace or to prevent [3H]ketanserin binding: these results were then compared to those obtained with [3H]spiperone in the frontal cortex. Although [3H]spiperone can be used to differentiate the affinity of a drug for serotonin (frontal cortex) and dopamine (striatum) receptors, the great advantage of [3H]ketanserin is that it labels serotonin S2-receptors exclusively. |
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Authors:
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P M Laduron; P F Janssen; J E Leysen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 81 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1982 Jun |
Date Detail:
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Created Date: 1982-12-02 Completed Date: 1982-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 43-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / metabolism* Ketanserin Male Piperidines / metabolism* Rats Rats, Inbred Strains Receptors, Serotonin / metabolism* Serotonin Antagonists / metabolism* Spiperone / metabolism Tritium |
| Chemical | |
Reg. No./Substance:
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0/Piperidines; 0/Receptors, Serotonin; 0/Serotonin Antagonists; 10028-17-8/Tritium; 74050-98-9/Ketanserin; 749-02-0/Spiperone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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