Document Detail

In vivo binding of [3H]ketanserin on serotonin S2-receptors in rat brain.
MedLine Citation:
PMID:  7117369     Owner:  NLM     Status:  MEDLINE    
In vivo binding of [3H]ketanserin was studied in various brain regions in rats. After i.v. injection of [3H]ketanserin (5 micrograms . kg-1), the highest labelling was found in the frontal cortex. Brain disposition of labelled drug correlated with the distribution of serotonin S2-receptors detected in vitro. The binding was saturable in the serotonergic areas but not in the cerebellum. Various drugs were tested for their ability to displace or to prevent [3H]ketanserin binding: these results were then compared to those obtained with [3H]spiperone in the frontal cortex. Although [3H]spiperone can be used to differentiate the affinity of a drug for serotonin (frontal cortex) and dopamine (striatum) receptors, the great advantage of [3H]ketanserin is that it labels serotonin S2-receptors exclusively.
P M Laduron; P F Janssen; J E Leysen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  81     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  43-8     Citation Subset:  IM    
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MeSH Terms
Brain / metabolism*
Piperidines / metabolism*
Rats, Inbred Strains
Receptors, Serotonin / metabolism*
Serotonin Antagonists / metabolism*
Spiperone / metabolism
Reg. No./Substance:
0/Piperidines; 0/Receptors, Serotonin; 0/Serotonin Antagonists; 10028-17-8/Tritium; 74050-98-9/Ketanserin; 749-02-0/Spiperone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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