Document Detail


In vivo autoradiography and planimetry of epidermis in psoriatics under PUVA-therapy.
MedLine Citation:
PMID:  7387176     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of oral 8-methoxypsoralen-photochemotherapy (PUVA)-therapy) on involved epidermis of nine psoriatics and on normal skin of four control subjects was investigated by means of in vivo autoradiography and planimetry. Under PUVA-therapy there is a significant decrease of 3H-TdR labeled cells per epidermal cross-sectional surface, per length of basal membrane and per length of epidermal surface. There is also a significant decrease of epidermal thickness. In the initial phase of PUVA-therapy the decrease of 3H-TdR labeled cells is the most pronounced. The reduction of epidermal thickness is less than the decrease of 3H-TdR labeled cells.
Authors:
C Hofmann; M Landthaler; G Plewig; O Braun-Falco
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of dermatological research     Volume:  267     ISSN:  0340-3696     ISO Abbreviation:  Arch. Dermatol. Res.     Publication Date:  1980  
Date Detail:
Created Date:  1980-08-25     Completed Date:  1980-08-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8000462     Medline TA:  Arch Dermatol Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  61-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Autoradiography
Epidermis / drug effects,  pathology
Humans
Male
Methoxsalen / pharmacology*
Middle Aged
Photochemotherapy*
Psoriasis / drug therapy*,  pathology
Skin / drug effects*
Chemical
Reg. No./Substance:
298-81-7/Methoxsalen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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