| In vivo autofluorescence characteristics of pre- and post-treated oral submucous fibrosis: a pilot study. | |
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MedLine Citation:
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PMID: 19884705 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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AIMS AND OBJECTIVES: To compare the autofluorescence spectra of oral submucous fibrosis (OSF) with normal mucosa, the autofluorescence spectra of OSF before and after treatment with intralesional dexamethasone and hyaluronidase, the clinical improvement following treatment with the changes in autofluorescence spectra and to prove that autofluorescence spectroscopy is a good method for diagnosis and assessment of treatment effectiveness in OSF. MATERIALS AND METHODS: The study was conducted at the Department of Oral Medicine and Radiology, Tamilnadu Government Dental College and Hospital, Chennai and Division of Medical Physics and Lasers, Department of Physics, Anna University, Chennai in 20 patients seeking medical management for symptomatic OSF and 20 patients who had dental caries only without any oral mucosal diseases and oral habits were used as normal controls. Their ages ranged from 20 to 40 years, including both male and female. In vivo fluorescence emission spectra were obtained using a handheld optical fiber probe attached to a Fluoromax-2 spectrofluorometer. RESULTS: The fluorescence spectrum of OSF had an intense fluorescence emission at 385 nm with a secondary emission peak at 440 nm compared with that of the normal oral mucosa. The average fluorescence spectrum of the post treated OSF mucosa had a lesser intensity around 385 nm and a higher intensity around 440 nm than that of the pre treated OSF mucosa, thereby mimicking the normal oral mucosa. All the three clinical parameters (maximal mouth opening, tongue protrusion and the severity of burning sensation) showed a high statistical significance, with P < 0.001, as in the case of classification of pre treated OSF mucosa from the post treated OSF mucosa using the autofluorescence technique. CONCLUSION: The change in the fluorescence emission spectrum for both normal and OSF mucosa before and after treatment can be explained by analyzing the changes in the fluorescence intensity of the endogenous fluorophores. |
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Authors:
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C Ponranjini Vedeswari; S Jayachandran; S Ganesan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of dental research : official publication of Indian Society for Dental Research Volume: 20 ISSN: 1998-3603 ISO Abbreviation: Indian J Dent Res Publication Date: 2009 Jul-Sep |
Date Detail:
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Created Date: 2009-11-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9202990 Medline TA: Indian J Dent Res Country: India |
Other Details:
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Languages: eng Pagination: 261-7 Citation Subset: D |
Affiliation:
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Department of Oral Medicine and Radiology, Government Dental College and Hospital, Chennai, Tamil Nadu, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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