| In vivo assessment of rapid cerebrovascular morphological adaptation following acute blood flow increase. | |
| | |
MedLine Citation:
|
PMID: 19035734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECT: Pathological extremes in cerebrovascular remodeling may contribute to basilar artery (BA) dolichoectasia and fusiform aneurysm development. Factors regulating cerebrovascular remodeling are poorly understood. To better understand hemodynamic influences on cerebrovascular remodeling, we examined BA remodeling following common carotid artery (CCA) ligation in an animal model. METHODS: Rabbits were subjected to sham surgery (3 animals), unilateral CCA ligation (3 animals), or bilateral CCA ligation (5 animals). Transcranial Doppler ultrasonography and rotational angiography were used to compute BA flow, diameter, wall shear stress (WSS), and a tortuosity index on Days 0, 1, 4, 7, 14, 28, 56, and 84. Basilar artery tissues were stained and analyzed at Day 84. Statistical analysis was performed using orthogonal contrast analysis, repeated measures analysis of variance, or mixed regression analysis of repeated measures. Statistical significance was defined as a probability value < 0.05. RESULTS: Basilar artery flow and diameter increased significantly after the procedure in both ligation groups, but only the bilateral CCA ligation group demonstrated significant differences between groups. Wall shear stress significantly increased only in animals in the bilateral CCA ligation group and returned to baseline by Day 28, with 52% of WSS correction occurring by Day 7. Only the bilateral CCA ligation group developed significant BA tortuosity, occurring within 7 days postligation. Unlike the animals in the sham and unilateral CCA ligation groups, the animals in the bilateral CCA ligation group had histological staining results showing a substantial internal elastic lamina fragmentation. CONCLUSIONS: Increased BA flow results in adaptive BA remodeling until WSS returns to physiological baseline levels. Morphological changes occur rapidly following flow alteration and do not require chronic insult to affect substantial and significant structural transformation. Additionally, it appears that there exists a flow-increase threshold that, when surpassed, results in significant tortuosity. |
| | |
Authors:
|
Yiemeng Hoi; Ling Gao; Markus Tremmel; Rocco A Paluch; Adnan H Siddiqui; Hui Meng; J Mocco |
Related Documents
:
|
1192704 - The role of baroreceptors and chemoreceptors in the regulation of the cerebral circulat... 3611124 - A numerical and experimental analysis of the flow field in a two-dimensional model of t... 1442434 - Color-flow doppler sonography in the identification of ulcerative plaques in patients w... 11762544 - Pattern of doppler flow indices at the carotid bifurcation: evaluation by hemodynamic c... 14566134 - The effect of the bovine hemoglobin oxygen therapeutic hboc-201 on human neutrophil act... 20660144 - Performance of high flow rate samplers for respirable particle collection. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Journal of neurosurgery Volume: 109 ISSN: 0022-3085 ISO Abbreviation: J. Neurosurg. Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-11-27 Completed Date: 2009-01-07 Revised Date: 2011-01-17 |
Medline Journal Info:
|
Nlm Unique ID: 0253357 Medline TA: J Neurosurg Country: United States |
Other Details:
|
Languages: eng Pagination: 1141-7 Citation Subset: AIM; IM |
Affiliation:
|
Toshiba Stroke Research Center, State University of New York at Buffalo, New York 14214, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Animals Basilar Artery / anatomy & histology*, physiology*, ultrasonography Brain / blood supply Carotid Artery, Common / surgery Cerebral Angiography Cerebrovascular Circulation / physiology* Female Models, Animal Rabbits Regional Blood Flow / physiology* Regression Analysis Ultrasonography, Doppler, Transcranial Vasodilation / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
EB002873/EB/NIBIB NIH HHS; K25 NS047242-05/NS/NINDS NIH HHS; NS043924/NS/NINDS NIH HHS; NS047242/NS/NINDS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clazosentan, an endothelin receptor antagonist, prevents early hypoperfusion during the acute phase ...
Next Document: Effect of electrical stimulation of the cervical spinal cord on blood flow following subarachnoid he...