Document Detail


In vivo assessment of optimal b-value range for perfusion-insensitive apparent diffusion coefficient imaging.
MedLine Citation:
PMID:  22894409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To assess the optimal b-values range for perfusion-insensitive apparent diffusion coefficient (ADC) imaging of abdominal organs using short-duration DW-MRI acquisitions with currently available ADC estimation methods.
METHODS: DW-MRI data of 15 subjects were acquired with eight b-values in the range of 5-800 s∕mm(2). The reference-standard, a perfusion insensitive, ADC value (ADC(IVIM)), was computed using an intravoxel incoherent motion (IVIM) model with all acquired diffusion-weighted images. Simulated DW-MRI data was generated using an IVIM model with b-values in the range of 0-1200 s∕mm(2). Monoexponential ADC estimates were calculated using: (1) Two-point estimator (ADC(2)); (2) least squares three-point (ADC(3)) estimator and; (3) Rician noise model estimator (ADC(R)). The authors found the optimal b-values for perfusion-insensitive ADC calculations by minimizing the relative root mean square error (RRMS) between the ADC(IVIM) and the monoexponential ADC values for each estimation method and organ.
RESULTS: Low b-value = 300 s∕mm(2) and high b-value = 1200 s∕mm(2) minimized the RRMS between the estimated ADC and the reference-standard ADC(IVIM) to less than 5% using the ADC(3) estimator. By considering only the in vivo DW-MRI data, the combination of low b-value = 270 s∕mm(2) and high b-value of 800 s∕mm(2) minimized the RRMS between the estimated ADC and the reference-standard ADC(IVIM) to <7% using the ADC(3) estimator. For all estimators, the RRMS between the estimated ADC and the reference standard ADC correlated strongly with the perfusion-fraction parameter of the IVIM model (r = [0.78-0.83], p ≤ 0.003).
CONCLUSIONS: The perfusion compartment in DW-MRI signal decay correlates strongly with the RRMS in ADC estimates from short-duration DW-MRI. The impact of the perfusion compartment on ADC estimations depends, however, on the choice of b-values and estimation method utilized. Likewise, perfusion-related errors can be reduced to <7% by carefully selecting the b-values used for ADC calculations and method of estimation.
Authors:
Moti Freiman; Stephan D Voss; Robert V Mulkern; Jeannette M Perez-Rossello; Michael J Callahan; Simon K Warfield
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Medical physics     Volume:  39     ISSN:  0094-2405     ISO Abbreviation:  Med Phys     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-16     Completed Date:  2012-10-02     Revised Date:  2013-08-12    
Medline Journal Info:
Nlm Unique ID:  0425746     Medline TA:  Med Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4832-9     Citation Subset:  IM    
Affiliation:
Moti Freiman, Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston Massachusetts 02115, USA. moti.freiman@childrens.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Abdomen / pathology*
Adolescent
Adult
Algorithms
Child
Computer Simulation
Diagnostic Imaging / methods
Diffusion
Diffusion Magnetic Resonance Imaging / methods*
Female
Humans
Image Processing, Computer-Assisted
Least-Squares Analysis
Likelihood Functions
Magnetic Resonance Imaging / methods
Male
Models, Statistical
Perfusion
Reproducibility of Results
Grant Support
ID/Acronym/Agency:
R01 EB008015/EB/NIBIB NIH HHS; R01 LM010033/LM/NLM NIH HHS; R01 RR021885/RR/NCRR NIH HHS; R03 EB008680/EB/NIBIB NIH HHS
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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