Document Detail

In vivo assessment of lung inflammatory cell activity in patients with COPD and asthma.
MedLine Citation:
PMID:  12762337     Owner:  NLM     Status:  MEDLINE    
The involvement of inflammatory cells in the pathogenesis of chronic obstructive pulmonary disease (COPD) and asthma is well established. This study aimed to quantify differences in inflammatory cell function in situ in these patients as compared to normal subjects. Positron emission tomography was used to assess neutrophil activity (18F-fluorodeoxyglucose (18FDG)) and macrophage accumulation (11C-PK11195) in six patients with COPD, six chronic asthmatics and five age-matched normal control subjects. 18FDG uptake was greater in COPD than in normal subjects, with no increase in asthmatics. The mean slope of 18FDG uptake, corrected for volume of distribution, was 4.0 min(-1) in COPD patients compared with 1.5 min(-1) in control subjects and 1.7 min(-1) in asthmatics. Mean 11C-PK11195 uptake (plateau tissue:plasma) was higher in four of six COPD patients (10.8) and three of five asthmatics (11.8) than the maximum value in control subjects (6.2). From this preliminary study the authors conclude that positron emission tomography may be useful to assess polymorphonuclear neutrophil and macrophage activity in vivo in chronic obstructive pulmonary disease and asthma, and may reveal differences in cell behaviour between the study groups. In addition, positron emission tomography may provide indices of disease activity for future therapeutic studies.
H A Jones; P S Marino; B H Shakur; N W Morrell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  21     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-05-23     Completed Date:  2003-09-04     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  567-73     Citation Subset:  IM    
Division of Medicine and National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK.
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MeSH Terms
Analysis of Variance
Asthma / immunology*,  radionuclide imaging*
Case-Control Studies
Cell Count
Fluorodeoxyglucose F18 / diagnostic use
Isoquinolines / diagnostic use
Macrophages / immunology
Middle Aged
Neutrophils / immunology
Pilot Projects
Pulmonary Disease, Chronic Obstructive / immunology*,  radionuclide imaging*
Radiopharmaceuticals / diagnostic use
Sputum / cytology
Tomography, Emission-Computed*
Reg. No./Substance:
0/Isoquinolines; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18; 85340-56-3/PK 11195

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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