Document Detail

In vivo assessment of iron and ascorbic acid in psoriatic dermis.
MedLine Citation:
PMID:  15040469     Owner:  NLM     Status:  MEDLINE    
Reactive oxygen species play an important role in inflammatory skin diseases such as psoriasis. Reactive oxygen species synthesis is catalysed by iron and some species are scavenged by ascorbic acid. The aim of this work was to assess iron and ascorbic acid in uninvolved and involved psoriatic dermis and to compare the corresponding concentrations in the dermis of healthy subjects. Microdialysis associated with atomic absorption spectrometry and gas chromatography-mass spectrometry was used to assess iron and ascorbic acid, respectively. Seven psoriatic patients and five healthy volunteers were studied. Iron concentrations in the involved (57.1 +/- 19.3 microg/l) and uninvolved (49.7 +/- 27.1 microgl/l) psoriatic dermis were higher than the corresponding value determined in the dermis of healthy subjects (21.8 +/- 2.4 microg/l) (p<0.05). Ascorbic acid in involved (47.3 +/- 8.2 microg/ml) and uninvolved (42.0 +/- 14.0 microg/ml) psoriatic dermis was statistically lower than that found in healthy dermis (176.8 +/- 29.0 microg/ml) (p<0.05). These results demonstrate that psoriatic patients exhibit high iron and low ascorbic acid concentrations in the dermis, but there were no significant differences between involved and uninvolved skin.
Nathalie Leveque; Sophie Robin; Patrice Muret; Sophie Mac-Mary; Safwat Makki; Alain Berthelot; Jean Pierre Kantelip; Philippe Humbert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  84     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  2004  
Date Detail:
Created Date:  2004-03-25     Completed Date:  2004-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  2-5     Citation Subset:  IM    
Laboratory of Cutaneous Bioengineering, Faculty of Medicine and Pharmacy, Besançon, France.
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MeSH Terms
Ascorbic Acid / analysis*
Gas Chromatography-Mass Spectrometry
Iron / analysis*
Middle Aged
Psoriasis / metabolism*
Skin / chemistry*
Spectrophotometry, Atomic
Reg. No./Substance:
50-81-7/Ascorbic Acid; 7439-89-6/Iron

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