| In vivo assessment of MR elastography-derived effective end-diastolic myocardial stiffness under different loading conditions. | |
| | |
MedLine Citation:
|
PMID: 21509882 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To compare magnetic resonance elastography (MRE) effective stiffness to end-diastolic pressure at different loading conditions to demonstrate a relationship between myocardial MRE effective stiffness and end-diastolic left ventricular (LV) pressure. MATERIALS AND METHODS: MRE was performed on four pigs to measure the end-diastolic effective stiffness under different loading conditions. End-diastolic pressure was increased by infusing Dextran-40 (20% of blood volume). For each infusion of Dextran-40, end-diastolic pressure was recorded and end-diastolic effective stiffness was measured using MRE. In each pig, least-square linear regression was performed to determine the correlation between end-diastolic effective stiffness and end-diastolic LV pressure. RESULTS: A linear correlation was found between end-diastolic LV pressure and end-diastolic effective stiffness with R(2) ranging from 0.73-0.9. A linear correlation with R(2) = 0.26 was found between end-diastolic LV pressure and end-diastolic effective stiffness when pooling data points from all pigs. CONCLUSION: End-diastolic effective myocardial stiffness increases linearly with end-diastolic LV pressure. |
| | |
Authors:
|
Arunark Kolipaka; Kiaran P McGee; Armando Manduca; Nandan Anavekar; Richard L Ehman; Philip A Araoz |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of magnetic resonance imaging : JMRI Volume: 33 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-04-21 Completed Date: 2011-10-03 Revised Date: 2012-05-01 |
Medline Journal Info:
|
Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
|
Languages: eng Pagination: 1224-8 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
|
Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure Diastole Elasticity Imaging Techniques / methods* Female Heart Ventricles / pathology Image Processing, Computer-Assisted Magnetic Resonance Imaging / methods* Male Myocardium / pathology* Pressure Regression Analysis Swine Ventricular Function, Left / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
EB001981/EB/NIBIB NIH HHS; EB007593/EB/NIBIB NIH HHS; R01 EB001981-12/EB/NIBIB NIH HHS; R01 EB001981-13/EB/NIBIB NIH HHS; R01 EB007593-01A2/EB/NIBIB NIH HHS; R01 EB007593-02/EB/NIBIB NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: On the use of a spin-echo based double inversion recovery acquisition for the measurement of cortica...
Next Document: Quantification of background enhancement in breast magnetic resonance imaging.