Document Detail

In vivo assessment of MR elastography-derived effective end-diastolic myocardial stiffness under different loading conditions.
MedLine Citation:
PMID:  21509882     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare magnetic resonance elastography (MRE) effective stiffness to end-diastolic pressure at different loading conditions to demonstrate a relationship between myocardial MRE effective stiffness and end-diastolic left ventricular (LV) pressure.
MATERIALS AND METHODS: MRE was performed on four pigs to measure the end-diastolic effective stiffness under different loading conditions. End-diastolic pressure was increased by infusing Dextran-40 (20% of blood volume). For each infusion of Dextran-40, end-diastolic pressure was recorded and end-diastolic effective stiffness was measured using MRE. In each pig, least-square linear regression was performed to determine the correlation between end-diastolic effective stiffness and end-diastolic LV pressure.
RESULTS: A linear correlation was found between end-diastolic LV pressure and end-diastolic effective stiffness with R(2) ranging from 0.73-0.9. A linear correlation with R(2) = 0.26 was found between end-diastolic LV pressure and end-diastolic effective stiffness when pooling data points from all pigs.
CONCLUSION: End-diastolic effective myocardial stiffness increases linearly with end-diastolic LV pressure.
Arunark Kolipaka; Kiaran P McGee; Armando Manduca; Nandan Anavekar; Richard L Ehman; Philip A Araoz
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  33     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-21     Completed Date:  2011-10-03     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1224-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA.
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MeSH Terms
Blood Pressure
Elasticity Imaging Techniques / methods*
Heart Ventricles / pathology
Image Processing, Computer-Assisted
Magnetic Resonance Imaging / methods*
Myocardium / pathology*
Regression Analysis
Ventricular Function, Left / physiology
Grant Support
EB001981/EB/NIBIB NIH HHS; EB007593/EB/NIBIB NIH HHS; R01 EB001981-12/EB/NIBIB NIH HHS; R01 EB001981-13/EB/NIBIB NIH HHS; R01 EB007593-01A2/EB/NIBIB NIH HHS; R01 EB007593-02/EB/NIBIB NIH HHS

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