Document Detail


In vivo assessment of 111In-labeled hematoporphyrin derivative in breast tumor-bearing animals.
MedLine Citation:
PMID:  2523878     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The biological behavior of 111In-labeled HPD has been investigated in tumor-bearing animals. Mice mammary adenocarcinomas and 7,12-dimethylbenz(a)anthracine induced breast tumors in Sprague-Dawley female rats were clearly visualized by 111In-HPD nuclear scintigraphy. Optimal scans were obtained after a 48 h delay. In normal and tumor-bearing animals, the highest uptake of 111In-HPD 72 h post-injection was found in the liver, the spleen and the kidneys. Depending on the size and the extent of necrosis, the uptake of 111In-HPD by malignant breast tumors varied from 2.5% injected dose (ID) (range 0.14-5.3% ID) in mice to 1% (range 0.22-8.1% ID) in rats. Benign breast tumor uptake of 111In-HPD was less than 1% ID. No significant amount of the radiopharmaceutical was found in pulmonary abscesses and abdominal cysts (less than 0.1% ID). Scintigrams of these infectious or inflammatory lesions were normal. Malignant tumor to blood, heart and lung ratios averaged 50:1, 10:1 and 3:1 respectively. Tumor to brain ratio ranged from 72 to 444:1.
Authors:
D W Wong; A Mandal; J Brown; I C Reese; R Siegler; S Hyman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology     Volume:  16     ISSN:  0883-2897     ISO Abbreviation:  Int J Rad Appl Instrum B     Publication Date:  1989  
Date Detail:
Created Date:  1989-06-22     Completed Date:  1989-06-22     Revised Date:  2008-02-21    
Medline Journal Info:
Nlm Unique ID:  8611098     Medline TA:  Int J Rad Appl Instrum B     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  269-81     Citation Subset:  IM    
Affiliation:
Department of Radiology, King/Drew Medical Center, U.C.L.A. 90059.
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MeSH Terms
Descriptor/Qualifier:
9,10-Dimethyl-1,2-benzanthracene
Adenocarcinoma / metabolism,  radionuclide imaging*
Animals
Female
Hematoporphyrin Derivative
Hematoporphyrins / diagnostic use,  pharmacokinetics*
Indium Radioisotopes / diagnostic use*
Mammary Neoplasms, Experimental / chemically induced,  metabolism,  radionuclide imaging*
Mice
Rats
Rats, Inbred Strains
Tissue Distribution
Chemical
Reg. No./Substance:
0/Hematoporphyrins; 0/Indium Radioisotopes; 57-97-6/9,10-Dimethyl-1,2-benzanthracene; 68335-15-9/Hematoporphyrin Derivative

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