| In vivo antitumor activity of novel water-soluble taxoids. | |
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MedLine Citation:
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PMID: 18520047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antitumor activity of newly developed taxoids possessing a sugar moiety (glucose, galactose or mannose) to improve water solubility was evaluated. Galactose-bound taxoid (10-alpha-GAG-DT) proved superior to all other taxoids in both water solubility and antitumor activity. Therapeutic efficacy of 10-alpha-GAG-DT in terms of in vivo antitumor activity was found to be approximately equivalent to that of docetaxel, which is known to be superior to that of paclitaxel. The observation that the sugar moiety was gradually hydrolyzed in serum to release docetaxel indicates that 10-alpha-GAG-DT acts as a prodrug. |
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Authors:
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Katsuhiko Mikuni; Katsuyoshi Nakanishi; Koji Hara; Kozo Hara; Wakao Iwatani; Tetsuya Amano; Kosho Nakamura; Yoshinori Tsuchiya; Hiroshi Okumoto; Tadakatsu Mandai |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biological & pharmaceutical bulletin Volume: 31 ISSN: 0918-6158 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-03 Completed Date: 2008-06-30 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
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Languages: eng Pagination: 1155-8 Citation Subset: IM |
Affiliation:
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Ensuiko Sugar Refining Co., Ltd., Fukuura, Yokohama, Japan. mikuni_k@ensuiko.co.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents, Phytogenic* Body Weight / drug effects Chemistry, Physical Drug Screening Assays, Antitumor Humans Indicators and Reagents Leukemia P388 / drug therapy Male Mice Physicochemical Phenomena Solubility Taxoids / chemistry, pharmacology* Water |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Indicators and Reagents; 0/Taxoids; 114977-28-5/docetaxel; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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