Document Detail


In vivo angiotensin II receptor blockade and converting enzyme inhibition on canine aortic viscoelasticity.
MedLine Citation:
PMID:  9124449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of the renin-angiotensin system (RAS) on the aortic wall mechanical properties under angiotensin I converting enzyme inhibition (enalaprilat, 0.3 mg/kg iv) or angiotensin II receptor (AT1) blockade (E-3174, 1 mg/kg iv) was examined in eight normotensive and eight renovascular hypertensive conscious dogs. Aortic diameter (D; sonomicrometry)-pressure (P; microtransducer) hysteresis loops during steady state and during rapid distal aortic occlusion allowed (after hysteresis elimination) calculation of the aortic wall viscosity index, the purely elastic P-D relationship, and derivation into compliance-pressure curves. At the early stage ofrenovascular hypertension when activation of RAS is more pronounced, aortic wall stiffness and wall viscosity were increased as compared with normotensive states. Blood pressure remained unchanged in normotensive animals and was reduced during hypertension after antihypertensive treatments. In hypertensive animals, enalaprilat and E-3174 decreased viscosity index and shifted the compliance-pressure curve upward with respect to pretreatment conditions. In normotensive dogs, whereas E-3174 did not change the compliance-pressure curve and viscosity index, enalaprilat increased compliance and reduced viscosity index. We concluded that in normotensive dogs converting enzyme inhibition modifies arterial viscoelastic parameters by angiotensin-independent mechanisms that contribute to the modulation of the buffering function of large arteries.
Authors:
J G Barra; J Levenson; R L Armentano; E I Cabrera Fischer; R H Pichel; A Simon
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  272     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-04-22     Completed Date:  1997-04-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H859-68     Citation Subset:  IM    
Affiliation:
Basic Sciences Research Institute, The René Favaloro University Foundation, Buenos Aires, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin I / antagonists & inhibitors
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Animals
Antihypertensive Agents / pharmacology
Aorta / drug effects*,  metabolism,  physiology*
Blood Pressure / drug effects
Dogs
Elasticity
Enalaprilat / pharmacology
Hypertension, Renovascular / physiopathology
Imidazoles / pharmacology
Male
Receptors, Angiotensin / antagonists & inhibitors*
Reference Values
Tetrazoles / pharmacology
Viscosity
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Imidazoles; 0/Receptors, Angiotensin; 0/Tetrazoles; 124750-92-1/EXP3174; 84680-54-6/Enalaprilat; 9041-90-1/Angiotensin I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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