Document Detail


In vivo analgesic and anti-inflammatory activities of ursolic acid and oleanoic acid from Miconia albicans (Melastomataceae).
MedLine Citation:
PMID:  16989305     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this work was to use in vivo models to evaluate the analgesic and anti-inflammatory activities of ursolic acid (UA) and oleanoic acid (OA), the major compounds isolated as an isomeric mixture from the crude methylene chloride extract of Miconia albicans aerial parts in an attempt to clarify if these compounds are responsible for the analgesic properties displayed by this plant. Ursolic acid inhibited abdominal constriction in a dose-dependent manner, and the result obtained at a content of 40 mg kg(-1) was similar to that produced by administration of acetylsalicylic acid at a content of 100 mg kg(-1). Both acids reduced the number of paw licks in the second phase of the formalin test, and both of them displayed a significant anti-inflammatory effect at a content of 40 mg kg(-1). It is noteworthy that the administration of the isolated mixture, containing 65% ursolic acid/35% oleanolic acid, did not display significant analgesic and anti-inflammatory activities. On the basis of the obtained results, considering that the mixture of UA and OA was poorly active, it is suggested that other compounds, rather than UA and OA, should be responsible for the evaluated activities in the crude extract, since the crude extract samples displayed good activities.
Authors:
Maria Anita L Vasconcelos; Vanessa A Royo; Daniele S Ferreira; Antonio E Miller Crotti; Márcio L Andrade e Silva; José Carlos T Carvalho; Jairo Kenupp Bastos; Wilson R Cunha
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zeitschrift für Naturforschung. C, Journal of biosciences     Volume:  61     ISSN:  0939-5075     ISO Abbreviation:  Z. Naturforsch., C, J. Biosci.     Publication Date:    2006 Jul-Aug
Date Detail:
Created Date:  2006-09-22     Completed Date:  2006-11-07     Revised Date:  2009-11-04    
Medline Journal Info:
Nlm Unique ID:  8912155     Medline TA:  Z Naturforsch C     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  477-82     Citation Subset:  IM    
Affiliation:
Universidade de Franca, Av. Dr. Armando Salles de Oliveira, 201 Parque Universitário, Franca-SP, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Analgesics / pharmacology*
Animals
Anti-Inflammatory Agents / pharmacology*
Brazil
Carrageenan
Chromatography, Liquid
Constriction, Pathologic / prevention & control
Edema / prevention & control
Melastomataceae / chemistry*
Mice
Molecular Structure
Oleanolic Acid / isolation & purification,  pharmacology*
Rats
Triterpenes / isolation & purification,  pharmacology*
Chemical
Reg. No./Substance:
0/Analgesics; 0/Anti-Inflammatory Agents; 0/Triterpenes; 508-02-1/Oleanolic Acid; 77-52-1/ursolic acid; 9000-07-1/Carrageenan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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