Document Detail


In vivo acquisition of hemozoin by placental blood mononuclear cells suppresses PGE2, TNF-alpha, and IL-10.
MedLine Citation:
PMID:  14623257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In areas of high malaria endemicity, women have increased susceptibility to malaria during pregnancy characterized by placental parasitemia. Our previous studies in children with malaria demonstrate that suppression of leukocyte-derived prostaglandin-E(2) (PGE(2)) is associated with enhanced pathogenesis. To examine the role of PGE(2) as an immunoregulatory molecule in placental malaria, PGE(2) was determined in cultured intervillous blood mononuclear cells (IVBMCs) from aparasitemic and parasitemic women. PGE(2) was significantly lower in parasitemic women at all gravidities. Women with a positive antenatal peripheral parasitemia who were negative for placental malaria (PM) at term produced the highest PGE(2) levels. Suppression of PGE(2) was associated with increasing amounts of hemozoin (malarial pigment) acquired during the natural infection. PGE(2) regulatory cytokines, tumor necrosis factor (TNF)-alpha and interleukin (IL)-10, were non-significantly increased in IVBMC containing an intermediate amount of hemozoin and significantly suppressed in IVBMC with high levels of hemozoin. Results presented here show that in vivo acquisition of high levels of hemozoin by IVBMC leads to decreased synthesis of PGE(2), IL-10, and TNF-alpha.
Authors:
Douglas J Perkins; Julie M Moore; Juliana Otieno; Ya Ping Shi; Bernard L Nahlen; Venkatachalam Udhayakumar; Altaf A Lal
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  311     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-18     Completed Date:  2004-02-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  839-46     Citation Subset:  IM    
Affiliation:
Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
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MeSH Terms
Descriptor/Qualifier:
Cells, Cultured
Chorionic Villi / drug effects,  immunology,  metabolism
Dinoprostone / metabolism*
Female
Hemeproteins / immunology,  metabolism*
Humans
Interleukin-10 / metabolism*
Leukocytes, Mononuclear / immunology,  metabolism*
Malaria / blood,  classification,  immunology,  metabolism*
Phytohemagglutinins / pharmacology
Placenta / drug effects,  immunology,  metabolism
Placenta Diseases / blood,  classification,  immunology,  metabolism*
Plant Proteins*
Pregnancy
Severity of Illness Index
Tumor Necrosis Factor-alpha / metabolism*
Grant Support
ID/Acronym/Agency:
AI-07217/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Hemeproteins; 0/Phytohemagglutinins; 0/Plant Proteins; 0/Tumor Necrosis Factor-alpha; 0/phytohemagglutinin L protein, Phaseolus vulgaris; 130068-27-8/Interleukin-10; 363-24-6/Dinoprostone; 39404-00-7/hemozoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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