Document Detail

In-vivo accuracy of geometrically correct three-dimensional reconstruction of human coronary arteries: is it influenced by certain parameters?
MedLine Citation:
PMID:  16905967     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The geometrically correct three-dimensional reconstruction of human coronary arteries by integrating intravascular ultrasound (IVUS) and biplane angiography constitutes a promising imaging method for coronaries with broad clinical potential. The determinants of the accuracy of the method, however, have not been investigated before. METHODS: In total, 17 arterial segments (right coronary artery, n=7; left anterior descending, n=4; left circumflex, n=6) derived from nine patients were three-dimensionally reconstructed by applying three-dimensional intravascular ultrasound. The degree of matching between the reconstructed lumen back-projected onto each angiographic plane and the actual lumen in each plane was used as a measure of method's accuracy. The investigated factors that could potentially affect the reliability of the method included the type of the artery (left anterior descending, left circumflex, right coronary artery) and several geometrical and morphological characteristics of the reconstructed arteries. RESULTS: The correlation between the back-projected reconstructed lumens and the actual angiographic ones was found to be high (r=0.78, P<0.001). Neither the category of the reconstructed arteries nor their particular geometrical and morphological characteristics influenced the accuracy of the reconstruction method significantly. Nonetheless, the method exhibited slightly less accuracy in the reconstruction of right coronary arteries, an observation that could be attributed to the more intense pulsatile motion that this artery experiences during the cardiac cycle compared to the left anterior descending and left circumflex artery. CONCLUSIONS: The in-vivo accuracy of three-dimensional intravascular ultrasound (3D IVUS) is significantly high regardless of the type of the coronary arteries or their particular geometrical and morphological characteristics. This finding further supports the applicability of the method for either diagnostic or investigational purposes.
Yiannis S Chatzizisis; George D Giannoglou; Antonis Matakos; Chrysanthi Basdekidou; George Sianos; Alexandros Panagiotou; Christos Dimakis; George E Parcharidis; George E Louridas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Coronary artery disease     Volume:  17     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-14     Completed Date:  2007-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  545-51     Citation Subset:  IM    
Cardiovascular Engineering and Atherosclerosis Laboratory, 1st Cardiology Department, AHEPA University Hospital, Aristotle University Medical School, Thessaloniki, Greece.
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MeSH Terms
Analysis of Variance
Coronary Angiography / methods*
Coronary Vessels / anatomy & histology*,  ultrasonography
Image Processing, Computer-Assisted*
Imaging, Three-Dimensional*
Middle Aged
Reproducibility of Results
Statistics, Nonparametric
Ultrasonography, Interventional / methods*

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