| In vivo absorption of aluminium-containing vaccine adjuvants using 26Al. | |
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MedLine Citation:
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PMID: 9302736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aluminium hydroxide (AH) and aluminium phosphate (AP) adjuvants, labelled with 26Al, were injected intramuscularly (i.m.) in New Zealand White rabbits. Blood and urine samples were collected for 28 days and analysed for 26Al using accelerator mass spectrometry to determine the absorption and elimination of AH and AP adjuvants. 26Al was present in the first blood sample (1 h) for both adjuvants. The area under the blood level curve for 28 days indicates that three times more aluminium was absorbed from AP adjuvant than AH adjuvant. The distribution profile of aluminium to tissues was the same for both adjuvants (kidney > spleen > liver > heart > lymph node > brain). This study has demonstrated that in vivo mechanisms are available to eliminate aluminium-containing adjuvants after i.m. administration. In addition, the pharmacokinetic profiles of AH and AP adjuvants are different. |
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Authors:
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R E Flarend; S L Hem; J L White; D Elmore; M A Suckow; A C Rudy; E A Dandashli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Vaccine Volume: 15 ISSN: 0264-410X ISO Abbreviation: Vaccine Publication Date: 1997 Aug-Sep |
Date Detail:
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Created Date: 1997-10-23 Completed Date: 1997-10-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8406899 Medline TA: Vaccine Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1314-8 Citation Subset: IM |
Affiliation:
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Department of Physics, Purdue University, West Lafayette, IN 47907, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Adjuvants, Immunologic / pharmacokinetics* Aluminum Compounds / pharmacokinetics* Aluminum Hydroxide / pharmacokinetics* Animals Female Phosphates / pharmacokinetics* Rabbits Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Aluminum Compounds; 0/Phosphates; 13765-93-0/aluminum phosphate; 21645-51-2/Aluminum Hydroxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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