Document Detail

In vivo absorption of aluminium-containing vaccine adjuvants using 26Al.
MedLine Citation:
PMID:  9302736     Owner:  NLM     Status:  MEDLINE    
Aluminium hydroxide (AH) and aluminium phosphate (AP) adjuvants, labelled with 26Al, were injected intramuscularly (i.m.) in New Zealand White rabbits. Blood and urine samples were collected for 28 days and analysed for 26Al using accelerator mass spectrometry to determine the absorption and elimination of AH and AP adjuvants. 26Al was present in the first blood sample (1 h) for both adjuvants. The area under the blood level curve for 28 days indicates that three times more aluminium was absorbed from AP adjuvant than AH adjuvant. The distribution profile of aluminium to tissues was the same for both adjuvants (kidney > spleen > liver > heart > lymph node > brain). This study has demonstrated that in vivo mechanisms are available to eliminate aluminium-containing adjuvants after i.m. administration. In addition, the pharmacokinetic profiles of AH and AP adjuvants are different.
R E Flarend; S L Hem; J L White; D Elmore; M A Suckow; A C Rudy; E A Dandashli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Vaccine     Volume:  15     ISSN:  0264-410X     ISO Abbreviation:  Vaccine     Publication Date:    1997 Aug-Sep
Date Detail:
Created Date:  1997-10-23     Completed Date:  1997-10-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1314-8     Citation Subset:  IM    
Department of Physics, Purdue University, West Lafayette, IN 47907, USA.
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MeSH Terms
Adjuvants, Immunologic / pharmacokinetics*
Aluminum Compounds / pharmacokinetics*
Aluminum Hydroxide / pharmacokinetics*
Phosphates / pharmacokinetics*
Tissue Distribution
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Aluminum Compounds; 0/Phosphates; 13765-93-0/aluminum phosphate; 21645-51-2/Aluminum Hydroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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