| In vivo visualization of reactive gliosis using manganese-enhanced magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 19909819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reactive astrogliosis occurs after diverse central nervous system (CNS) insults. While astrogliosis provides protection against inflammation, it is also obstructive in the progress of neuranagenesis after CNS insults. Thus, a method that enables in vivo visualization and tissue characterization for gliosis would be invaluable for studies of CNS insults and corresponding treatments. Manganese has proven to be a useful MRI contrast agent that enters cells via Ca(2+) channels and has been applied to manganese-enhanced MRI (MEMRI) for neuronal functional mapping. This study investigated whether MEMRI can detect astrogliosis after focal ischemia in vivo. Rats were divided into groups according to the number of days after either transient middle cerebral artery occlusion or a sham. Ring- or crescent-shaped enhancement of MEMRI corresponded to the GFAP-positive astroglia observed in the peripheral region of the ischemic core 11 days after middle cerebral artery occlusion. This indicates that MEMRI enhancement predominantly reflects reactive astrogliosis after stroke. |
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Authors:
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Yuko Kawai; Ichio Aoki; Masahiro Umeda; Toshihiro Higuchi; Jeff Kershaw; Makoto Higuchi; Afonso C Silva; Chuzo Tanaka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-10 |
Journal Detail:
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Title: NeuroImage Volume: 49 ISSN: 1095-9572 ISO Abbreviation: Neuroimage Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-04-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: United States |
Other Details:
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Languages: eng Pagination: 3122-31 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Neurosurgery, Meiji University of Integrative Medicine, Kyoto, 629-0392, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / pathology* Brain Diseases / pathology* Chlorides / diagnostic use* Contrast Media Gliosis / pathology* Image Enhancement / methods* Magnetic Resonance Imaging / methods* Male Manganese Compounds / diagnostic use* Rats Rats, Sprague-Dawley Reproducibility of Results Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Chlorides; 0/Contrast Media; 0/Manganese Compounds; 7773-01-5/manganese chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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