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In vivo Neuroprotective Activity of Epopeptide AB Against Ischemic Damage.
MedLine Citation:
PMID:  19003054     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Erythropoietin (Epo) is a hematopoietic factor, which stimulates proliferation and differentiation of erythroid precursor cells. Epo also functions as a neuroprotective factor and protects neurons from ischemic damage. Recently a 17-mer peptide sequence (Epopeptide AB) in Epo (AEHCSLNENITVPDTKV) with a neuroprotective function was reported. In this study, we showed in vivo evidence that Epopeptide AB protected neurons from ischemic damage at similar dose compared to Epo. Epopeptide AB could not stimulate the proliferation of Epo-dependent growing murine myeloid Ep-FDC-P2 cells and also did not compete the proliferative function of Epo on these cells. Together with these results, Epopeptide AB did not transduce signals through direct binding to the known Epo receptor on hematopoietic cells but has neuroprotective activity against ischemia.
Authors:
Masaya Nagao; Tong-Chun Wen; Masaya Okamoto; Kazuhiro Irie; Takeshi Takaku; Masahiro Sakanaka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cytotechnology     Volume:  47     ISSN:  0920-9069     ISO Abbreviation:  Cytotechnology     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2011-07-14     Revised Date:  2013-03-07    
Medline Journal Info:
Nlm Unique ID:  8807027     Medline TA:  Cytotechnology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  -    
Affiliation:
Laboratory of Biosignals and Response, Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, 606-8502, Kyoto, Japan, mnagao@kais.kyoto-u.ac.jp.
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