Document Detail


In vivo NGF treatment increases proliferation in the primary sympathetic ganglia of chick embryos.
MedLine Citation:
PMID:  9015269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nerve growth factor (NGF) is considered to be a target-derived survival or differentiation factor for neural crest cells of the sympathoadrenal lineage. However, exogenous NGF was found to have a positive effect on the size of the primary sympathetic ganglia (PSG) of the chick embryo, well before sympathetic innervation of the periphery. We have determined the cellular mechanism of NGF's action on the PSG by quantifying both proliferation and apoptosis. The proportion of PSG cells in S-phase is nearly double in NGF-treated embryos compared to that in controls, strongly suggesting that NGF acts as a mitogenic factor. NGF reduced the low level of apoptosis at this stage as well. Since trkA has not been detected in the avian sympathetic ganglia until later in development, we suggest that these early effects of exogenous NGF may be mediated by the low-affinity neurotrophin receptor, p75, which is expressed from neural crest migration stages.
Authors:
R S Goldstein; C Avivi; R Geffen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental biology     Volume:  181     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-02-27     Completed Date:  1997-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  116-20     Citation Subset:  IM    
Affiliation:
Department of Life Sciences, Bar- Ilan University, Ramat-Gan, Israel.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / drug effects
Cell Division / drug effects
Chick Embryo
Ganglia, Sympathetic / cytology,  drug effects*
Nerve Growth Factors / pharmacology*
Receptor, Nerve Growth Factor
Receptors, Nerve Growth Factor / physiology
S Phase / drug effects
Chemical
Reg. No./Substance:
0/Nerve Growth Factors; 0/Receptor, Nerve Growth Factor; 0/Receptors, Nerve Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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