| In vivo MRI assessment of permanent middle cerebral artery occlusion by electrocoagulation: pitfalls of procedure. | |
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MedLine Citation:
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PMID: 20298536 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Permanent middle cerebral artery (MCA) occlusion (pMCAO) by electrocoagulation is a commonly used model but with potential traumatic lesions. Early MRI monitoring may assess pMCAO for non-specific brain damage. The surgical steps of pMCAO were evaluated for traumatic cerebral injury in 22 Swiss mice using diffusion and T2-weighted MRI (7T) performed within 1 h and 24 h after surgery. Temporal muscle cauterization without MCA occlusion produced an early T2 hyperintensity mimicking an infarct. No lesion was visible after temporal muscle incision or craniotomy. Early MRI monitoring is useful to identify non-specific brain injury that could hamper neuroprotective drugs assessment. |
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Authors:
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Fabien Chauveau; Samir Moucharrafie; Marlène Wiart; Jean-Christophe Brisset; Yves Berthezène; Norbert Nighoghossian; Tae-Hee Cho |
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Publication Detail:
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Type: Journal Article Date: 2010-02-04 |
Journal Detail:
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Title: Experimental & translational stroke medicine Volume: 2 ISSN: 2040-7378 ISO Abbreviation: Exp Transl Stroke Med Publication Date: 2010 |
Date Detail:
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Created Date: 2010-03-19 Completed Date: 2010-05-20 Revised Date: 2010-09-28 |
Medline Journal Info:
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Nlm Unique ID: 101519930 Medline TA: Exp Transl Stroke Med Country: England |
Other Details:
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Languages: eng Pagination: 4 Citation Subset: - |
Affiliation:
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CREATIS, CNRS UMR 5220, INSERM U 630, Université Claude Bernard Lyon I, France. |
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